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•Intestinal oxidative stress depends on the balance of ROS.•The antioxidant defense system protects intestine from oxidative stress damage.•Phytochemicals with health effects could be ...developed to nutritional supplements.
Oxidative stress occurs when there exists an imbalance between the generation and elimination of reactive oxygen species (ROS). As inevitable exposure to foreign substances and microbial pathogens, intestine is a key resource of ROS. Disproportionate generation and long-term exposure to ROS lead to various intestinal diseases, such as inflammatory bowel diseases (IBD), enteric infections, ischemic intestinal injury and colorectal cancers. Natural nutrients including vitamins, proteins, fats, minerals and phytochemicals provide numerous evidences that they can protect the health of intestine and alleviate the damage caused by oxidative stress, which can be developed as novel functional foods. This review summarized the recent research progress on the insights of the causes, mechanisms of intestinal oxidative stress and the health intervention effects of nutrients. This review has also given the prospects that the new discovered nutrients with health benefits might be developed as novel functional foods or possible nutraceutical agents.
The purpose of this work was to meta-analyze empirical evidence about the effectiveness of digital-based interventions for students with mathematical learning difficulties. Furthermore, we ...investigated whether the school level of the participants and the software instructional approach were decisive modulated factors. A systematic search of randomized controlled studies published between 2003 and 2019 was conducted. A total of 15 studies with 1073 participants met the study selection criterion. A random effects meta-analysis indicated that digital-based interventions generally improved mathematical performance (mean ES = 0.55), though there was a significant heterogeneity across studies. There was no evidence that videogames offer additional advantages with respect to digital-based drilling and tutoring approaches. Moreover, effect size was not moderated when interventions were delivered in primary school or in preschool.
•This meta-analysis investigated the effects of digital tools for students with mathematical learning difficulties.•Technological tools positively impact mathematics achievement of students with mathematical learning difficulties.•Interventions show similar effects for preschool and primary-school children.•Videogames do not offer additional advantages with respect to digital-based drilling and tutoring approaches.
Aim This study aims to verify the effectiveness of M-O-A telenursing intervention model in improving the health status and quality of life of the empty-nest older adult individuals with chronic ...diseases by a randomized comparative trial. Methods M-O-A telenursing intervention model was constructed based on the needs of the participants. The control group ( N = 39) received routine nursing, the experimental group ( N = 39) received M-O-A telenursing intervention in addition to routine nursing. After 12 weeks of intervention, the intervention effects of being a participant in the two groups were evaluated. SPSS 26.0 was used for data analysis. Results After 12 weeks of intervention, for the experimental group, each dimension of quality of life based on EQ-5D-3L became better, especially for “pain/discomfort,” “anxiety/depression,” “HRQoL” and “EQ-VAS” (all p < 0.05) and each dimension of quality of life based on SF-36 became better too, especially for “GH,” “BP,” “RE,” “MH,” “VT,” “SF,” “PCS,” “MCS,” “SF-36” (all p < 0.05). In addition, there was a statistical downward trend in blood pressure, blood glucose, weight, BMI, fat rate, nap duration, number of nocturnal awakenings, light sleep rate and a statistical upward trend in water rate, basal metabolic rate, nighttime sleep duration, deep sleep rate, rapid eye movement sleep rate, especially at the end of intervention (all p < 0.05). While for the control group, there was no statistical improvement in all these aspects. Conclusion The M-O-A telenursing model could effectively regulate quality of life and health condition of the empty-nest older adult individuals with chronic diseases, making it worthy of further promotion and application.
•Examining long-term effects of child maltreatment interventions is challenging.•This study examined collateral intervention effects on child maltreatment proxies.•The usefulness of administrative ...data in effectiveness research was also explored.•No evidence was found for collateral effects of three parent programs.•We conclude that administrative data can be very useful in effectiveness research.
Collecting child maltreatment data from participants is expensive and time-consuming, and often suffers from substantial attrition rates. Administrative population data may prove fruitful to overcome these barriers. The aim of this study was twofold: (1) to illustrate how administrative data may be used in evaluating long-term intervention effects; and (2) to examine collateral effects of three preventive early childhood interventions offered to families in the Netherlands (Supportive Parenting, VoorZorg, and Incredible Years). Using population data, four proxies of child maltreatment were assessed to examine collateral intervention effects: incidences of child protection orders, placements of children in residential care, crime victimization of children or their parents, and parental registrations as a crime suspect. The results revealed no significant differences between experimental and control conditions on any of these proxies, with very small effect sizes (ranging from Cramer’s V = 0.01 to Cramer’s V = 0.10). We conclude that the results do not provide support for collateral effects, but that studying other outcomes may provide this support. We further discuss that small sample sizes and low prevalences challenge studies using administrative data. Notwithstanding these limitations, we conclude that administrative data can strengthen the evidence base for collateral and direct intervention effects.
A few studies on relative-clause processing report an unexpected facilitatory effect on the matrix verb that follows an Object Relative (ORC) clause (e.g. Staub, Dillon and Clifton jr. 2017). In ...this study we present the results of a novel eye-tracking experiment that replicated this effect on Italian. The advantage of ORCs is discussed under the hypothesis that subject-verb agreement in the matrix benefits from a general trace-reactivation mechanisms, subsumed from activation-based retrieval models (Lewis and Vasishth 2005).
Abstract
Background
Improved sanitation has been associated with improved child growth in observational studies, but multiple randomized trials that delivered improved sanitation found no effect on ...child growth. We assessed to what extent differences in the effect estimated in the two study designs (the effect of treatment in observational studies and the effect of treatment assignment in trials) could explain the contradictory results.
Methods
We used parametric g-computation in five prospective studies (n = 21 524) and 59 cross-sectional Demographic and Health Surveys (DHS; n = 158 439). We compared the average treatment effect (ATE) for improved sanitation on mean length-for-age z-score (LAZ) among children aged <2 years to population intervention effects (PIEs), which are the observational analogue of the effect estimated in trials in which some participants are already exposed.
Results
The ATE was >0.15 z-scores, a clinically meaningful difference, in most prospective studies but in <20% of DHS surveys. The PIE was always smaller than the ATE, and the magnitude of difference depended on the baseline prevalence of the improved sanitation. Interventions with suboptimal coverage and interventions delivered in populations with higher mean LAZ had a smaller effect on population-level LAZ.
Conclusions
Estimates of PIEs corresponding to anticipated trial results were often smaller than clinically meaningful effects. Incongruence between observational associations and null trial results may in part be explained by expected differences between the effects estimated. Using observational ATEs to set expectations for trials may overestimate the impact that sanitation interventions can achieve. PIEs predict realistic effects and should be more routinely estimated.
Recent calls have been made to evaluate the range, rather than the frequency of use, of strategies within adolescents' emotion regulation repertoire. It is unknown whether an emotion regulation ...intervention may increase adolescents' emotion regulation repertoire. To examine the direct effect of an emotion regulation intervention on adolescents' perceived emotion regulation repertoire from baseline to immediately postintervention, when controlling for baseline problems with emotional awareness and participant sex. Seventh-grade students (N = 420) participated in a 6-week emotion regulation and sexual health promotion randomized control trial. Adolescent-report measures of emotion regulation and problems with emotional awareness were collected. On average, adolescents used one additional strategy after completing the intervention; they endorsed using four (out of eight) strategies at baseline and five strategies immediately after the intervention. Emotion regulation interventions may expand adolescents' repertoire. Future research should explore whether such expansion may guide downstream effects on psychosocial functioning and prevent health risk behaviors.
To examine developmental processes, intervention effects, or both, longitudinal studies often aim to include measurement intervals that are equally spaced for all participants. In reality, however, ...this goal is hardly ever met. Although different approaches have been proposed to deal with this issue, few studies have investigated the potential benefits of individual variation in time intervals. In the present paper, we examine how continuous time dynamic models can be used to study nonexperimental intervention effects in longitudinal studies where measurement intervals vary between and within participants. We empirically illustrate this method by using panel data (N = 2,877) to study the effect of the transition from primary to secondary school on students' motivation. Results of a simulation study also show that the precision and recovery of the estimate of the effect improves with individual variation in time intervals.
Calls continue for randomized interventions in organizational settings. In many cases, however, practical constraints require researchers to use 2-wave randomized pretest-posttest control group ...designs. We discuss the importance of randomized trials for theory development with a focus on analytic options for 2-wave designs. Our discussion has implications for both designing studies and interpreting results. We review 23 published work and organizational health psychology intervention studies and find that a majority of studies featured a statistical model known to have low statistical power relative to other options. Furthermore, a majority of studies invoked terminology implying the direction of change without providing explicit statistical tests. To improve research practice, we detail statistical power differences in 3 commonly used statistical models and emphasize the distinction between (a) intervention effects and (b) the size and direction of change over time. We encourage researchers to provide inferential evidence for both types of information and show that only 1 of the 3 reviewed models provides information on the direction of change over time, but at a potential expense for statistical power to detect intervention effects. A reanalysis of data from a published work-family workplace intervention illustrates these nuances and supports recommendations for research practice. We conclude by providing recommendations.
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