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  • Laminin-111 enriched fibrin... Laminin-111 enriched fibrin hydrogels for skeletal muscle regeneration
    Marcinczyk, Madison; Elmashhady, Hady; Talovic, Muhamed ... Biomaterials, October 2017, 2017-Oct, 2017-10-00, 20171001, Volume: 141
    Journal Article
    Peer reviewed

    Laminin (LM)-111 supplementation has improved muscle regeneration in several models of disease and injury. This study investigated a novel hydrogel composed of fibrinogen and LM-111. Increasing ...
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22.
  • Mechanisms regulating myobl... Mechanisms regulating myoblast fusion: A multilevel interplay
    Lehka, Lilya; Rędowicz, Maria Jolanta Seminars in cell & developmental biology, August 2020, 2020-08-00, 20200801, Volume: 104
    Journal Article
    Peer reviewed

    Myoblast fusion into myotubes is one of the crucial steps of skeletal muscle development (myogenesis). The fusion is preceded by specification of a myogenic lineage (mesodermal progenitors) ...
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23.
  • Crosslinking and compositio... Crosslinking and composition influence the surface properties, mechanical stiffness and cell reactivity of collagen-based films
    Grover, Chloe N.; Gwynne, Jessica H.; Pugh, Nicholas ... Acta biomaterialia, 08/2012, Volume: 8, Issue: 8
    Journal Article
    Peer reviewed
    Open access

    This study focuses on determining the effect of varying the composition and crosslinking of collagen-based films on their physical properties and interaction with myoblasts. Films composed of ...
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24.
  • The LRRC8/VRAC anion channe... The LRRC8/VRAC anion channel facilitates myogenic differentiation of murine myoblasts by promoting membrane hyperpolarization
    Chen, Lingye; Becker, Thorsten M.; Koch, Ursula ... The Journal of biological chemistry, 09/2019, Volume: 294, Issue: 39
    Journal Article
    Peer reviewed
    Open access

    Skeletal muscle myoblast differentiation involves elaborate signaling networks, including the activity of various ion channels and transporters. Several K+ and Ca2+ channels have been shown to affect ...
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25.
  • An artificial niche preserves the quiescence of muscle stem cells and enhances their therapeutic efficacy
    Quarta, Marco; Brett, Jamie O; DiMarco, Rebecca ... Nature biotechnology, 07/2016, Volume: 34, Issue: 7
    Journal Article
    Peer reviewed
    Open access

    A promising therapeutic strategy for diverse genetic disorders involves transplantation of autologous stem cells that have been genetically corrected ex vivo. A major challenge in such approaches is ...
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26.
  • Irisin, a Novel Myokine, Re... Irisin, a Novel Myokine, Regulates Glucose Uptake in Skeletal Muscle Cells via AMPK
    Lee, Hye Jeong; Lee, Jung Ok; Kim, Nami ... Molecular endocrinology (Baltimore, Md.), 06/2015, Volume: 29, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    Irisin is a novel myokine produced by skeletal muscle. However, its metabolic role is poorly understood. In the present study, irisin induced glucose uptake in differentiated skeletal muscle cells. ...
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27.
  • Role of hypoxia in skeletal... Role of hypoxia in skeletal muscle fibrosis: Synergism between hypoxia and TGF-β signaling upregulates CCN2/CTGF expression specifically in muscle fibers
    Valle-Tenney, Roger; Rebolledo, Daniela L.; Lipson, Kenneth E. ... Matrix biology, 20/May , Volume: 87
    Journal Article
    Peer reviewed

    Several skeletal muscle diseases are characterized by fibrosis, the excessive accumulation of extracellular matrix. Transforming growth factor-β (TGF-β) and connective tissue growth factor ...
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  • Stem cell therapy for muscu... Stem cell therapy for muscular dystrophies
    Biressi, Stefano; Filareto, Antonio; Rando, Thomas A The Journal of clinical investigation, 11/2020, Volume: 130, Issue: 11
    Journal Article
    Peer reviewed
    Open access

    Muscular dystrophies are a heterogeneous group of genetic diseases, characterized by progressive degeneration of skeletal and cardiac muscle. Despite the intense investigation of different ...
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  • LRRC8 channel activation an... LRRC8 channel activation and reduction in cytosolic chloride concentration during early differentiation of C2C12 myoblasts
    Chen, Lingye; König, Benjamin; Stauber, Tobias Biochemical and biophysical research communications, 11/2020, Volume: 532, Issue: 3
    Journal Article
    Peer reviewed
    Open access

    Leucine-rich repeat containing family 8 (LRRC8) proteins form the volume-regulated anion channel (VRAC). Recently, they were shown to be required for normal differentiation and fusion of C2C12 ...
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30.
  • Decreased myoblast differen... Decreased myoblast differentiation in chronic binge alcohol-administered simian immunodeficiency virus-infected male macaques: role of decreased miR-206
    Simon, L; Ford, Jr, S M; Song, K ... American journal of physiology. Regulatory, integrative and comparative physiology, 09/2017, Volume: 313, Issue: 3
    Journal Article
    Peer reviewed
    Open access

    Skeletal muscle stem cells play a critical role in regeneration of myofibers. We previously demonstrated that chronic binge alcohol (CBA) markedly attenuates myoblast differentiation potential and ...
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