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  • Issue Cover (February 2024) Issue Cover (February 2024)
    Journal of anatomy, 02/2024, Volume: 244, Issue: 2
    Journal Article
    Peer reviewed
    Open access

    Front cover:Cover image: A self‐organized renal organoid made by serial reaggregation of ex‐fetu mouse renogenic stem cells. Image credit: Veronika Ganeva and Jamie Davies. See paper by Davies, this ...
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  • Cell Types of the Human Ret... Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution
    Cowan, Cameron S.; Renner, Magdalena; De Gennaro, Martina ... Cell, 09/2020, Volume: 182, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    Human organoids recapitulating the cell-type diversity and function of their target organ are valuable for basic and translational research. We developed light-sensitive human retinal organoids with ...
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  • Homeostatic mini-intestines through scaffold-guided organoid morphogenesis
    Nikolaev, Mikhail; Mitrofanova, Olga; Broguiere, Nicolas ... Nature (London), 09/2020, Volume: 585, Issue: 7826
    Journal Article
    Peer reviewed

    Epithelial organoids, such as those derived from stem cells of the intestine, have great potential for modelling tissue and disease biology . However, the approaches that are used at present to ...
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  • Identification of SARS-CoV-2 inhibitors using lung and colonic organoids
    Han, Yuling; Duan, Xiaohua; Yang, Liuliu ... Nature (London), 01/2021, Volume: 589, Issue: 7841
    Journal Article
    Peer reviewed
    Open access

    There is an urgent need to create novel models using human disease-relevant cells to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) biology and to facilitate drug screening. Here, ...
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  • Brain organoids: advances, ... Brain organoids: advances, applications and challenges
    Qian, Xuyu; Song, Hongjun; Ming, Guo-Li Development (Cambridge), 04/2019, Volume: 146, Issue: 8
    Journal Article
    Peer reviewed
    Open access

    Brain organoids are self-assembled three-dimensional aggregates generated from pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic human brain. As such, they have ...
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  • Gut organoids: mini-tissues... Gut organoids: mini-tissues in culture to study intestinal physiology and disease
    Almeqdadi, Mohammad; Mana, Miyeko D; Roper, Jatin ... American Journal of Physiology: Cell Physiology, 09/2019, Volume: 317, Issue: 3
    Journal Article
    Peer reviewed
    Open access

    In vitro, cell cultures are essential tools in the study of intestinal function and disease. For the past few decades, monolayer cellular cultures, such as cancer cell lines or immortalized cell ...
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  • Generation, transcriptome p... Generation, transcriptome profiling, and functional validation of cone-rich human retinal organoids
    Kim, Sangbae; Lowe, Albert; Dharmat, Rachayata ... Proceedings of the National Academy of Sciences - PNAS, 05/2019, Volume: 116, Issue: 22
    Journal Article
    Peer reviewed
    Open access

    Rod and cone photoreceptors are light-sensing cells in the human retina. Rods are dominant in the peripheral retina, whereas cones are enriched in the macula, which is responsible for central vision ...
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  • Tissue geometry drives dete... Tissue geometry drives deterministic organoid patterning
    Gjorevski, N; Nikolaev, M; Brown, T E ... Science (American Association for the Advancement of Science), 2022-Jan-07, Volume: 375, Issue: 6576
    Journal Article
    Peer reviewed
    Open access

    Epithelial organoids are stem cell–derived tissues that approximate aspects of real organs, and thus they have potential as powerful tools in basic and translational research. By definition, they ...
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  • Intra-tumour diversification in colorectal cancer at the single-cell level
    Roerink, Sophie F; Sasaki, Nobuo; Lee-Six, Henry ... Nature (London), 04/2018, Volume: 556, Issue: 7702
    Journal Article
    Peer reviewed

    Every cancer originates from a single cell. During expansion of the neoplastic cell population, individual cells acquire genetic and phenotypic differences from each other. Here, to investigate the ...
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  • A three-dimensional model of human lung development and disease from pluripotent stem cells
    Chen, Ya-Wen; Huang, Sarah Xuelian; de Carvalho, Ana Luisa Rodrigues Toste ... Nature cell biology, 05/2017, Volume: 19, Issue: 5
    Journal Article
    Peer reviewed
    Open access

    Recapitulation of lung development from human pluripotent stem cells (hPSCs) in three dimensions (3D) would allow deeper insight into human development, as well as the development of innovative ...
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