Sparebøsser fra middelalderens Ribe Søvsø, Mette Højmark
By, marsk og geest - Kulturhistorisk tidsskrift for Sydvestjylland,
06/2022
Journal Article
Open access
I Ribes middelalderlag findes jævnligt større og mindre fragmenter af sparebøsser af keramik. Ved samlingsgennemgangeni forbindelse med indflytningen i det nye magasin dukker desuden jævnligt ...hidtilupåagtede skår af sparebøsser op, og Sydvestjyske Museer rummer efterhånden en hel lille samling afdenne genstandsgruppe. I det følgende præsenteres de sparebøsser og skår, som indtil nu er identificereti museets samling.
Studies have been conducted at synchrotron facilities in Europe and Australia to explore a variety of applications of synchrotron X-rays in medicine and biology. We discuss the major technical ...aspects of the synchrotron irradiation setups, paying specific attention to the Australian Synchrotron (AS) and the European Synchrotron Radiation Facility (ESRF) as those best configured for a wide range of biomedical research involving animals and future cancer patients. Due to ultra-high dose rates, treatment doses can be delivered within milliseconds, abiding by FLASH radiotherapy principles. In addition, a homogeneous radiation field can be spatially fractionated into a geometric pattern called microbeam radiotherapy (MRT); a coplanar array of thin beams of microscopic dimensions. Both are clinically promising radiotherapy modalities because they trigger a cascade of biological effects that improve tumor control, while increasing normal tissue tolerance compared to conventional radiation. Synchrotrons can deliver high doses to a very small volume with low beam divergence, thus facilitating the study of non-targeted effects of these novel radiation modalities in both in-vitro and in-vivo models. Non-targeted radiation effects studied at the AS and ESRF include monitoring cell–cell communication after partial irradiation of a cell population (radiation-induced bystander effect, RIBE), the response of tissues outside the irradiated field (radiation-induced abscopal effect, RIAE), and the influence of irradiated animals on non-irradiated ones in close proximity (inter-animal RIBE). Here we provide a summary of these experiments and perspectives on their implications for non-targeted effects in biomedical fields.
Experimental results on the application of reflectance anisotropy spectroscopy (RAS) to the monitoring of (reactive) ion etching of monocrystalline semiconductor samples are described. To show the ...potential of this technique RAS signals collected during etching of GaAs/AlxGa1−xAs multilayer samples are compared to RAS data obtained before during molecular-beam epitaxial (MBE) growth of these very samples. A change of the RIE-RAS spectrum can be attributed to a change of material composition. And the current etch depth can be monitored with an accuracy at least down to several tens of nanometers – f. e. by recording the average reflected intensity.
This paper presents a revised lithostratigraphic scheme for the uppermost Upper Oligocene – Miocene succession of Denmark. The marine Oligocene Brejning Clay Member is upgraded to formation status ...and includes the Sydklint Member and the Øksenrade Member (new). The shallow marine and deltaic deposits of mainly Early Miocene age are included in the Ribe Group (new) while the fully marine Middle and Upper Miocene clay-rich deposits are referred to the Måde Group (new). The Ribe Group is subdivided into 6 formations: the Vejle Fjord Formation is revised and includes the Skansebakke Member, the Billund Formation (new) includes the Addit and Hvidbjerg Members (new), the Klintinghoved Formation is redefined formally and includes the Koldingfjord Member (new), the Bastrup Formation (new) includes the Resen Member (new), the Vandel Member is a new member in the Arnum Formation (revised), the Odderup Formation is redefined and includes the Stauning Member (new) and the coalbearing Fasterholt Member. The Måde Group is subdivided into the Hodde, Ørnhøj (new), Gram and Marbæk (new) Formations. Subdivision of the Upper Oligocene – Miocene succession into two groups, the Ribe and Måde Groups, is compatible with the North Sea lithostratigraphic framework where they correlate with the upper part of the Hordaland Group and the Nordland Group, respectively.
The revised lithostratigraphic framework correlated in three dimensions provides rigorous constraints on the palaeogeographic interpretation of the Late Oligocene – Miocene period. Three major deltaic units (Billund, Bastrup and Odderup Formations) prograded from the north and north-east into the North Sea Basin during the Early – early Middle Miocene. Delta progradation was punctuated by deposition of marine clay and silt associated with minor transgressive events (Vejle Fjord, Klintinghoved and Arnum Formations). During the Middle–Late Miocene, marine depositional conditions dominated (Hodde, Ørnhøj and Gram Formations). A fourth and final progadational event (Marbæk Formation) commenced in the latest Tortonian heralding the emergence of present-day Denmark (including the North Sea sector).
Abstract
Purpose: Synchrotron microbeam radiation therapy (MRT) is a radiosurgery concept in the preclinical stage, developed mainly for brain tumor treatment. Experimental studies suggest that with ...MRT a better therapeutic index can be obtained than with homogenous field radiotherapy, but the underlying cellular mechanisms need further understanding. The aim of this study was to investigate the dynamics of radiation-induced bystander effects (RIBE) in rats after exposing one brain hemisphere to either MRT or homogenous synchrotron radiation (HSR).
Materials and methods: Healthy and tumor-bearing Wistar rats were exposed to doses of 17.5, 35, 70 or 350 Gy, applied either as MRT or HSR to the right cerebral hemisphere. Rats were euthanized at 4, 8 and 12 hours after irradiation to assess the release of bystander signals. Brains and urinary bladders were dissected, and explants for bystander clonogenic reporter assays were set up.
Results: Clonogenic survival showed that RIBE occurred in both the non-irradiated brain hemisphere and in bladder of normal and tumor-bearing rats, while the irradiated hemisphere showed the direct effects of radiation.
Conclusion: The RIBE observed in our reporter cells shows that both MRT and HSR yield a demonstrable abscopal effect after high doses of irradiation; presumably as part of a systemic response.
Bystander effects induced by low dose of ionizing radiation have been shown to widely exist in many cell types and may have a significant impact on radiation risk assessment. Though many studies have ...been reported on this phenomenological observation, the mechanisms underlying this process are not clear, especially on the questions of how soon after irradiation the bystander effects can be initiated and how far this bystander signal can be propagated once it is started. DNA double-strand breaks (DSBs) induced by ionizing radiation or carcinogenic chemicals can be visualized in situ using γ-H2AX immunofluorescent staining. Our previous studies have shown that in situ visualization of DSBs could be used to assess irradiation-induced extranuclear/extracellular (bystander) effect at an early stage after irradiation. In the present studies, we used this method to investigate the time and spatial effects of damage signals on unirradiated bystander cells. The results showed that increased DSBs in irradiated and unirradiated bystander areas could be visualized 2 min after radiation and reached its maximum 30 min after radiation. The average levels of DSB formation at 30 min post-1cGy irradiation in the irradiated and unirradiated bystander areas were 3-fold and 2-fold higher than those of the sham-irradiated control cells, respectively. Afterwards, the formation of DSBs declined with incubation time and remained steady for at least 6 h at a level that was statistically higher than their controls. The results also showed that the bystander signal derived from irradiated cells could be transferred to anywhere in the dish and the percentage of DSBs in the unirradiated bystander cells was not dependent on the dose delivered. Moreover, the fraction of DSB positive cells in unirradiated bystander areas showed a time-dependent increase based on its distance to the irradiated area at very early stage post-irradiation. Both lindane and DMSO significantly suppressed the yield of DSBs in the cells of unirradiated bystander areas, which suggest that gap junctional intercellular communication and reactive oxygen species played important roles in the induction of the bystander effects, both in irradiated and unirradiated bystander areas.
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