Across the West, hard-right leaders are surging to power on platforms of ethno-economic nationalism, Christianity, and traditional family values. Is this phenomenon the end of neoliberalism or its ...monstrous offspring? In the Ruins of Neoliberalism casts the hard-right turn as animated by socioeconomically aggrieved white working- and middle-class populations but contoured by neoliberalism's multipronged assault on democratic values. From its inception, neoliberalism flirted with authoritarian liberalism as it warred against robust democracy. It repelled social-justice claims through appeals to market freedom and morality. It sought to de-democratize the state, economy, and society and re-secure the patriarchal family. In key works of the founding neoliberal intellectuals, Wendy Brown traces the ambition to replace democratic orders with ones disciplined by markets and traditional morality and democratic states with technocratic ones. Yet plutocracy, white supremacy, politicized mass affect, indifference to truth, and extreme social disinhibition were no part of the neoliberal vision. Brown theorizes their unintentional spurring by neoliberal reason, from its attack on the value of society and its fetish of individual freedom to its legitimation of inequality. Above all, she argues, neoliberalism's intensification of nihilism coupled with its accidental wounding of white male supremacy generates an apocalyptic populism willing to destroy the world rather than endure a future in which this supremacy disappears.
Right ventricular failure predicts adverse outcome in patients with pulmonary hypertension (PH), and in subjects with left ventricular heart failure and is associated with interstitial fibrosis. This ...review manuscript discusses the cellular effectors and molecular mechanisms implicated in right ventricular fibrosis. The right ventricular interstitium contains vascular cells, fibroblasts, and immune cells, enmeshed in a collagen-based matrix. Right ventricular pressure overload in PH is associated with the expansion of the fibroblast population, myofibroblast activation, and secretion of extracellular matrix proteins. Mechanosensitive transduction of adrenergic signalling and stimulation of the renin-angiotensin-aldosterone cascade trigger the activation of right ventricular fibroblasts. Inflammatory cytokines and chemokines may contribute to expansion and activation of macrophages that may serve as a source of fibrogenic growth factors, such as transforming growth factor (TGF)-β. Endothelin-1, TGF-βs, and matricellular proteins co-operate to activate cardiac myofibroblasts, and promote synthesis of matrix proteins. In comparison with the left ventricle, the RV tolerates well volume overload and ischemia; whether the right ventricular interstitial cells and matrix are implicated in these favourable responses remains unknown. Expansion of fibroblasts and extracellular matrix protein deposition are prominent features of arrhythmogenic right ventricular cardiomyopathies and may be implicated in the pathogenesis of arrhythmic events. Prevailing conceptual paradigms on right ventricular remodelling are based on extrapolation of findings in models of left ventricular injury. Considering the unique embryologic, morphological, and physiologic properties of the RV and the clinical significance of right ventricular failure, there is a need further to dissect RV-specific mechanisms of fibrosis and interstitial remodelling.
Based on fieldwork among state officials, NGOs, politicians, and activists in Costa Rica and Brazil, A Future History of Water traces the unspectacular work necessary to make water access a human ...right and a human right something different from a commodity. Andrea Ballestero shows how these ephemeral distinctions are made through four technolegal devices—formula, index, list and pact. She argues that what is at stake in these devices is not the making of a distinct future but what counts as the future in the first place. A Future History of Water is an ethnographically rich and conceptually charged journey into ant-filled water meters, fantastical water taxonomies, promises captured on slips of paper, and statistical maneuvers that dissolve the human of human rights. Ultimately, Ballestero demonstrates what happens when instead of trying to fix its meaning, we make water’s changing form the precondition of our analyses.
During recent decades, radical right parties have been surging in popularity in many nations, gaining legislative seats, enjoying the legitimacy endowed by ministerial office, and striding the ...corridors of government power. The popularity of leaders such as Le Pen, Haider, and Fortuyn has aroused widespread popular concern and a burgeoning scholarly literature. Despite the interest, little consensus has emerged about the primary factors driving this phenomenon. The puzzle is to explain why radical right parties have advanced in a diverse array of democracies - including in Austria, Canada, Norway, France, Italy, New Zealand, Switzerland, Israel, Romania, Russia, and Chile - while failing to make comparable gains in similar societies elsewhere, such as in Sweden, Britain, and the United States. This book, first published in 2005, expands our understanding of support for radical right parties through presenting an integrated new theory which is then tested systematically using a wealth of cross-national survey evidence covering almost forty countries.
Development with a Body Cornwall, Andrea; Correa, Sonia; Jolly, Susie
2008, 2008-09-15, 2008-03-15, 20080101, Volume:
56217
eBook
Offers insights into contemporary challenges and transformative possibilities of the struggle for sexual rights. This book combines the conceptual with the political, and offering examples of ...practical interventions and campaigns that emphasize the positive dimensions of sexuality.
Though the extreme right was not particularly successful in the 1999 European elections, it continues to be a major factor in the politics of Western Europe. This book, newly available in paperback, ...provides a comprehensive and detailed analysis of the extreme right in the Netherlands (Centrumdemocraten, Centrumpartij'86), Belgium (Vlaams Blok) and Germany (Die Republikaner, Deutsche Volksunion). On the basis of original research - using party literature - the author concludes that though individual parties might stress different issues, the extreme right party family does share a core ideology of nationalism, xenophobia, welfare chauvinism, and law and order. The author's research and conclusions clearly have broader implications for the study of the extreme right phenomenon and party ideology in general, and the book should be of interest to anyone studying or researching in the areas of European politics, political ideologies, political parties, extremism, racism or nationalism.
Exercise is associated with unequivocal health benefits and results in many structural and functional changes of the myocardium that enhance performance and prevent heart failure. However, intense ...exercise also presents a significant hemodynamic challenge in which the right-sided heart chambers are exposed to a disproportionate increase in afterload and wall stress that can manifest as myocardial fatigue or even damage if intense exercise is sustained for prolonged periods. This review focuses on the physiological factors that result in a disproportionate load on the right ventricle during exercise and the long-term consequences. The changes in cardiac structure and function that define 'athlete's heart' disproportionately affect the right-sided heart chambers and this can raise important diagnostic overlap with some cardiac pathologies, particularly some inherited cardiomyopathies. The interaction between exercise and arrhythmogenic right ventricular cardiomyopathy (ARVC) will be highlighted as an important example of how hemodynamic stressors can combine with deficiencies in cardiac structural elements to cause cardiac dysfunction predisposing to arrhythmias. The extent to which extreme exercise can cause adverse remodelling in the absence of a genetic predisposition remains controversial. In the athlete with profound changes in heart structure, it can be extremely challenging to determine whether common symptoms such as palpitations may be a marker of more sinister arrhythmias. This review discusses some of the techniques that have recently been proposed to identify pathology in these circumstances. Finally, we will discuss recent evidence defining the role of exercise restriction as a therapeutic intervention in individuals predisposed to arrhythmogenic cardiomyopathy.
What threatens the property rights of business owners? And what makes these rights secure? This book transcends the conventional diagnosis of the issue in modern developing countries by moving beyond ...expropriation by the state ruler or by petty bureaucratic corruption. It identifies 'agent predation' as a novel threat type, showing it to be particularly widespread and detrimental. The book also questions the orthodox prescription: institutionalized state commitment cannot secure property rights against agent predation. Instead, this volume argues that business actors can hold the predatory state agents accountable through firm-level alliances with foreign actors, labor, and local communities. Beyond securing ownership, such alliances promote rule of law in a rent-seeking society. Taking Russia and Ukraine between 2000 and 2012 as its empirical focus, the book advances these arguments by drawing on more than 150 qualitative interviews with business owners, policy makers, and bureaucrats, as well as an original large-N survey of firms.
The other women’s movement Cobble, Dorothy Sue
2004., 20110815, 2011, 2003, 2004-01-01, Volume:
35
eBook
American feminism has always been about more than the struggle for individual rights and equal treatment with men. There's also a vital and continuing tradition of women's reform that sought social ...as well as individual rights and argued for the dismantling of the masculine standard. In this much anticipated book, Dorothy Sue Cobble retrieves the forgotten feminism of the previous generations of working women, illuminating the ideas that inspired them and the reforms they secured from employers and the state.
MicroRNAs in right ventricular remodelling Batkai, Sandor; Bär, Christian; Thum, Thomas
Cardiovascular research,
2017-Oct-01, 2017-10-01, 20171001, Volume:
113, Issue:
12
Journal Article
Peer reviewed
Open access
Right ventricular (RV) remodelling is a lesser understood process of the chronic, progressive transformation of the RV structure leading to reduced functional capacity and subsequent failure. Besides ...conditions concerning whole hearts, some pathology selectively affects the RV, leading to a distinct RV-specific clinical phenotype. MicroRNAs have been identified as key regulators of biological processes that drive the progression of chronic diseases. The role of microRNAs in diseases affecting the left ventricle has been studied for many years, however there is still limited information on microRNAs specific to diseases in the right ventricle. Here, we review recently described details on the expression, regulation, and function of microRNAs in the pathological remodelling of the right heart. Recently identified strategies using microRNAs as pharmacological targets or biomarkers will be highlighted. Increasing knowledge of pathogenic microRNAs will finally help improve our understanding of underlying distinct mechanisms and help utilize novel targets or biomarkers to develop treatments for patients suffering from right heart diseases.
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