Octahydroxanthene Compounds are bioactive substance which can be produced from benzaldehyde derivative. In this research, we have carried out transformation of vanilin from Indonesian natural product ...to octahydroxanthene derivatives compound at optimized reaction time and guanidine was used as a catalyst. Several spectroscopy methods such as IR, 1H-NMR and GC-MS were used to confirm the structure of product. The percent yield from optimation product obtained was 91% with 96% of peak area.
Flavour compound in vanilin (vanilin compound) is constructed during the production process of fresh vanilin bean into dry vanilin bean. The decreasing of vanilin level during the storage causes the ...decrease of quallity of vanilin level. This research is aimed to determine the kinetics decreasing of vailin level of dry vanilin in many plastic packaging during the storage. In this research, polietilen plastic (0,03 mm width), polipropilen (0,03 mm width) and plastic sack are used as the packaging of dry vanilin. The kinetic decreasing of vanilin level during the storage is determine by using Arrhenius kinetic. The result of this research shows that the decreasing of vanilin level in dry vanilin beans which are packaged by using polipropilen plastics is larger than packaged by using polietilen plastics and plastic sacks. The equation of the decreasing vanilin level for vanilin beans, packaged with polipropilen Y = -4030X + 9,685, polietilen Y = -3971X + 9,577 and plastic sacks Y = -3846X + 9,263.
SCOPE: Silicon (Si) is an abundant element on earth. It is found naturally in water in the form of orthosilicic acid (OSA), however this form is not stable under certain conditions such as in highly ...concentrated and non‐neutral pH solutions, which lead to its polymerization and reduced bioavailability. This study aimed to assess the bioavailability of Si from OSA stabilized by vanillin (OSA‐VC). METHODS AND RESULTS: This was a single‐center, double‐blind, cross‐over randomized controlled trial. Fourteen healthy subjects were recruited and consumed either OSA‐VC or a placebo on two separate occasions. Blood and urine samples were collected during 6 h following ingestion and analyzed to determine Si absorption and excretion. Plasma Si area under the curve (0–6 h) was significantly higher after OSA‐VC ingestion compared to placebo ingestion (p = 0.0002). Significantly higher urinary Si excretion was also reported over the 6‐h period after OSA‐VC ingestion compared to placebo (p<0.0001). Approximately 21% of ingested Si was excreted in urine during this period. CONCLUSION: Although many studies have investigated the metabolism and bioavailability of Si supplemented in foods or as a food ingredient, this was the first to investigate and demonstrate the digestibility of OSA administered in a complex form with vanillin.
Telah dilakukan sintesis kemosensor anion senyawa 4-(2,6-difenil-piridin-4-il)-2-metoksi-fenol (DPMF). Sintesis senyawa target DPMF dilakukan melalui senyawa antara kalkon dengan rendemen reaksi 77%. ...Uji sebagai sensor anion dilakukan dalam pelarut DMSO-air terhadap anion F-, Cl-, Br-, CN- dan H2PO4-. Senyawa DPMF ini menghasilkan perubahan warna dari tidak berwarna menjadi kuning pada penambahan anion CN-. Analisis spektrofotometer UV-vis pada senyawa DPMF menghasilkan perubahan λmak = 320 nm ke λmak = 370 nm pada penambahan anion CN-. Limit deteksi terhadap anion CN- sebesar 4,11x10-6M. Senyawa ini juga dapat berperan sebagai kemosensor fluoresen dengan sistem “ON-OFF”.
Metal complexes of Schiff base derived from condensation of o-vanilin (3-methoxysalicylaldehyde) and sulfametrole N(1)-(4-methoxy-1,2,5-thiadiazole-3-yl)sulfanilamide (H2L) are reported and ...characterized based on elemental analyses, IR, 1H NMR, solid reflectance, magnetic moment, molar conductance, mass spectra, UV-vis and thermal analysis (TGA). From the elemental analyses data, the complexes were proposed to have the general formulae M2X3(HL)(H2O)5.yH2O (where M=Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II), X=Cl, y=0-3); Fe2Cl5(HL)(H2O)3.2H2O; (FeSO4)2(H2L)(H2O)4 and (UO2)2(NO3)3(HL)(H2O).2H2O. The molar conductance data reveal that all the metal chelates were non-electrolytes. The IR spectra show that, H2L is coordinated to the metal ions in a tetradentate manner with ON and NO donor sites of the azomethine-N, phenolic-OH, enolic sulphonamide-OH and thiadiazole-N. From the magnetic and solid reflectance spectra, it is found that the geometrical structures of these complexes are octahedral. The thermal behaviour of these chelates shows that the hydrated complexes losses water molecules of hydration in the first step followed immediately by decomposition of the anions and ligand molecules in the subsequent steps. The activation thermodynamic parameters, such as, E*, DeltaH*, DeltaS* and DeltaG* are calculated from the DrTG curves using Coats-Redfern method. The synthesized ligand, in comparison to their metal complexes also were screened for their antibacterial activity against bacterial species, Escherichia coli, Salmonella typhi, Bacillus subtillus, Staphylococcus aureus and Fungi (Aspergillus terreus and Aspergillus flavus). The activity data show that the metal complexes to be more potent/antimicrobial than the parent Shciff base ligand against one or more microbial species.
Vanillin is generally synthesized from coniferin, cresol, ferulic acid, guaiacol, lignosulphonates, and vanillyl mandelic acid using oxidation-reduction methods with various chemicals and consecutive ...stages. These methods are less environmentally friendly due to their use of harmful compounds and the ineffective multistage process. In this study, we investigated electrochemical oxidation of isoeugenol to vanillin. A boron-doped diamond (BDD) modified by gold nanoparticles (AuNPs) was prepared for use as the working electrode, with sulfuric acid used as the electrolyte. Peak oxidation and reduction of BDD-AuNPs occurred at 1.20 V and 0.40 V, respectively, and a voltammetric range of −1.50 V to 1.50 V was applied to determine the potential oxidation of isoeugenol. The results indicated that the optimal pH for electrooxidation was 8, with potential oxidation occurring at 0.50 V.
Eco-friendly synthesis of imine derivative compound from 2-hydroxy acetophenone and vanillin had been conducted by using a method of stirring (with stirrer) in a water solvent. The whole experiment ...began with the synthesis of imine compounds, followed by purification and characterization of the synthesis products and finally analysis on their biological and antioxidant activities. The experiments showed that imine compounds could be synthesized by a chemical reaction of 4-amino antipirin aqueous solution with 2-hydroxy acetophenone and vanillin at magnetic stirrer speed of 250 and 450 rpm, respectively, which produced product A, (E)-4-(1-(2-hydroxyphenyl) ethylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one and product B, (E)-4-(4-hydroxy-3-(vinyloxy) benzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one. Yield percentage (%) obtained from the synthesis of product A and B were 40.68% and 19.76% respectively. Toxicity and antioxidant activity tests showed that the product B were toxic and more active as an antioxidant than product A. While the antibacterial activity test showed that both products had a response to Staphyllococcus aureus bacteria and Escherechia coli bacteria.
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