Revised and updated second edition of the bestselling hands-on guide to building enterprise-ready web apps using an evergreen Angular platformKey FeaturesUpdated examples, projects, and a new ...overview of tools - including NgRX and Ivy, automated testing, and Firebase authenticationNew chapter summarizing history of web frameworks and Angular version updatesAll-new RESTful API implementation leveraging the MEAN stack with MongoDB, Express.js, Angular and Node.jsBook DescriptionThis second edition of Angular for Enterprise-Ready Web Applications is updated with in-depth coverage of the evergreen Angular platform.You'll start by mastering Angular programming fundamentals. Using the Kanban method and GitHub tools, you'll build great-looking apps with Angular Material and also leverage reactive programming patterns with RxJS, discover the flux pattern with NgRx, become familiar with automated testing, utilize continuous integration using CircleCI, and deploy your app to the cloud using Vercel Now and GCloud.You will then learn how to design and develop line-of-business apps using router-first architecture with observable data anchors, demonstrated through oft-used recipes like master/detail views, and data tables with pagination and forms. Next, you'll discover robust authentication and authorization design demonstrated via integration with Firebase, API documentation using Swagger, and API implementation using the MEAN stack.Finally, you will learn about DevOps using Docker, build a highly available cloud infrastructure on AWS, capture user behavior with Google Analytics, and perform load testing. By the end of the book, you'll be familiar with the entire gamut of modern web development and full-stack architecture, learning patterns and practices to be successful as an individual developer on the web or as a team in the enterprise.What you will learnAdopt a minimalist, value-first approach to delivering web appsMaster Angular development fundamentals, RxJS, CLI tools, GitHub, and DockerDiscover the flux pattern and NgRxImplement a RESTful APIs using Node.js, Express.js, and MongoDBCreate secure and efficient web apps for any cloud provider or your own serversDeploy your app on highly available cloud infrastructure using DevOps, CircleCI, and AWSWho this book is forThis book is for developers who want to confidently deliver high-quality and production-grade Angular apps from design to deployment. Developers that have prior experience in writing a RESTful APIs will also benefit, as well as developers who will gain greater awareness of how they fit into the larger picture of delivering a web application. Prior experience with RESTful APIs is desired.
Learn end-to-end automation testing techniques for web and mobile browsers using Selenium WebDriver, AppiumDriver, Java, and TestNGKey FeaturesExplore the Selenium grid architecture and build your ...own grid for browser and mobile devicesUse ExtentReports for processing results and SauceLabs for cloud-based test servicesUnlock the full potential of Selenium to test your web applications.Book DescriptionSelenium WebDriver 3.x is an open source API for testing both browser and mobile applications. With the help of this book, you can build a solid foundation and can easily perform end-to-end testing on web and mobile browsers.You'll begin by being introduced to the Selenium Page Object Model for software development. You'll architect your own framework with a scalable driver class, Java utility classes, and support for third-party tools and plugins. You'll design and build a Selenium grid from scratch to enable the framework to scale and support different browsers, mobile devices, and platforms.You'll strategize and handle a rich web UI using the advanced WebDriver API and learn techniques to handle real-time challenges in WebDriver. You'll perform different types of testing, such as cross-browser testing, load testing, and mobile testing. Finally, you will also be introduced to data-driven testing, using TestNG to create your own automation framework.By the end of this Learning Path, you'll be able to design your own automation testing framework and perform data-driven testing with Selenium WebDriver.This Learning Path includes content from the following Packt products:Selenium WebDriver 3 Practical Guide - Second Edition by Unmesh GundechaSelenium Framework Design in Data-Driven Testing by Carl CocchiaroWhat you will learnUse different mobile and desktop browser platforms with Selenium 3Use the Actions API for performing various keyboard and mouse actionsDesign the Selenium Driver Class for local, remote, and third-party grid supportBuild page object classes with the Selenium Page Object ModelDevelop data-driven test classes using the TestNG frameworkEncapsulate data using the JSON protocolBuild a Selenium Grid for RemoteWebDriver testingBuild and use utility classes in synchronization, file I/O, reporting and test listener classesWho this book is forThis Learning Path is ideal for software quality assurance/testing professionals, software project managers, or software developers interested in using Selenium for testing their applications. Professionals responsible for designing and building enterprise-based testing frameworks will also find this Learning Path useful. Prior programming experience in Java are TestNG is necessary.
Santrauka. IT pletros konteksto atvilgiu taikomos teisines priemones nesugeba ispresti problemu, su kuriomis tenka susidurti visuomenei, antra vertus, tam tikrais atvejais stabdoma inovaciju ...pletra. Informaciniu sistemu ir technologiju pletros intensyvumas reikalauja labai lanksciu ir adaptyviu kibernetines saugos utikrinimo metodu taikymo budu. Vienas i iu metodu - IT rizikos vertinimas. iuo metu yra daug metodologijij, kuriomis remiantis butu galima efektyviai vertinti kibernetiniu gresmiu rizika. Istaigai, turinciai daugybe riziku, skirtingu poziciju koreliacija gali buti neteisingai ivertinta. inomos rizikos matavimas yra dana rizikos vertinimo praktikos problema. Siekiant sukurti paprasta IT rizikos vertinimo metoda, straipsnyje nagrinejami esami IT rizikos vertinimo metodai, siulomi IT rizikos vertinimo sprendimai ir pateikiami praktinio pritaikymo rezultatai. Reikminiai odiai: IT rizikos, metodas, kibernetinis saugumas, paeidiamumas, gresmes.
The two articles bundled in Part II of this special issue detail the technological environment in which the social physics authoring workshop took place, from the perspective of the researchers who ...built certain key elements. Daniel DeKerlegand’s contribution describes the custom authoring tool he designed, which served as the group’s main interface during our week of remote meetings, sharing solutions to challenges around facilitating the transformation of literary data into formats readable by the Ensemble social physics engine. Paul François then completes the reflection on the project’s technical framework by putting the workshop’s social physics coding goals in conversation with his previous work designing the immersive VR restitution of an eighteenth-century Fair theatre that serves as the experiential frame for the VESPACE experience. This article is part of the collection Computer Modelling and Simulation for Literary-Historical Research: VESPACE and Social Physics.Les deux articles regroupés dans la partie II de ce numéro spécial détaillent l’environnement technologique dans lequel se déroula l’atelier de création en physique sociale, du point de vue des chercheurs qui ont construit certains éléments clés. La contribution de Daniel DeKerlegand décrit l’outil de codage qu’il a conçu exprès pour cet atelier, qui servit d’interface principale du groupe pendant notre semaine de réunions à distance, et relate des solutions aux verrous techniques liés à la facilitation de la transformation des données littéraires en formats lisibles par le moteur de physique sociale Ensemble. Paul François complète ensuite la réflexion sur le cadre technique du projet en mettant en conversation les objectifs de codage en physique sociale de l’atelier avec son travail précédent de conception de la restitution immersive en réalité virtuelle d’un Théâtre de foire du XVIIIe siècle qui sert de cadre expérientiel pour l’expérience VESPACE. Cet article fait partie de la collection Modélisation et simulation informatiques pour la recherche littéraire-historique : VESPACE et physique sociale.
Data mining of The Cancer Genome Atlas (TCGA) data has significantly facilitated cancer genome research and provided unprecedented opportunities for cancer researchers. However, existing web ...applications for DNA methylation analysis does not adequately address the need of experimental biologists, and many additional functions are often required.
To facilitate DNA methylation analysis, we present the SMART (Shiny Methylation Analysis Resource Tool) App, a user-friendly and easy-to-use web application for comprehensively analyzing the DNA methylation data of TCGA project. The SMART App integrates multi-omics and clinical data with DNA methylation and provides key interactive and customized functions including CpG visualization, pan-cancer methylation profile, differential methylation analysis, correlation analysis and survival analysis for users to analyze the DNA methylation in diverse cancer types in a multi-dimensional manner.
The SMART App serves as a new approach for users, especially wet-bench scientists with no programming background, to analyze the scientific big data and facilitate data mining. The SMART App is available at http://www.bioinfo-zs.com/smartapp.
Abstract
Prognostic models that aim to improve the prediction of clinical events, individualized treatment and decision-making are increasingly being developed and published. However, relatively few ...models are externally validated and validation by independent researchers is rare. External validation is necessary to determine a prediction model’s reproducibility and generalizability to new and different patients. Various methodological considerations are important when assessing or designing an external validation study. In this article, an overview is provided of these considerations, starting with what external validation is, what types of external validation can be distinguished and why such studies are a crucial step towards the clinical implementation of accurate prediction models. Statistical analyses and interpretation of external validation results are reviewed in an intuitive manner and considerations for selecting an appropriate existing prediction model and external validation population are discussed. This study enables clinicians and researchers to gain a deeper understanding of how to interpret model validation results and how to translate these results to their own patient population.
Svelte is a modern framework for building static web apps running in the browser that can be used to create fast, lean apps, and which is fun for developers to use. This thorough and quick start ...guide will explore the components of Svelte and have you up and running with building a complete production-ready, static web app in no time.
The rapid expansion of the CRISPR toolbox through tagging effector domains to either enzymatically inactive Cas9 (dCas9) or Cas9 nickase (nCas9) has led to several promising new gene editing ...strategies. Recent additions include CRISPR cytosine or adenine base editors (CBEs and ABEs) and the CRISPR prime editors (PEs), in which a deaminase or reverse transcriptase are fused to nCas9, respectively. These tools hold great promise to model and correct disease-causing mutations in animal and plant models. But so far, no widely-available tools exist to automate the design of both BE and PE reagents.
We developed PnB Designer, a web-based application for the design of pegRNAs for PEs and guide RNAs for BEs. PnB Designer makes it easy to design targeting guide RNAs for single or multiple targets on a variant or reference genome from organisms spanning multiple kingdoms. With PnB Designer, we designed pegRNAs to model all known disease causing mutations available in ClinVar. Additionally, PnB Designer can be used to design guide RNAs to install or revert a SNV, scanning the genome with one CBE and seven different ABE PAM variants and returning the best BE to use. PnB Designer is publicly accessible at http://fgcz-shiny.uzh.ch/PnBDesigner/ CONCLUSION: With PnB Designer we created a user-friendly design tool for CRISPR PE and BE reagents, which should simplify choosing editing strategy and avoiding design complications.
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