5q-syndrome is a rare form of myelodysplastic syndrome (MDS) characterized by deletion in the region of the long arm of chromosome 5. Clinically, it presents as mild or moderate anemia accompanied by ...elevated or normal plateletcount and normal or slightly elevated leukocyte count. Clinical and laboratory findings are nonspecific and may mimic those in myeloproliferative disorder, especially essential thrombocytemia. Bone marrow changes are often inconspicuous and may be more easily found in bone marrow biopsy specimens. Cytogenetic confirmation is required for definite diagnosis. Since 5q-syndromehas favorable prognosis, its delineation from other forms of MDS isclinically important. We report a 69-year-old female patient who had been treated for hypertension and throm- bembolisms and in whom a mild anemia and thrombocytosis were found in 1995. A myelo- proliferative disorder was suspected and bone marrow aspiration was performed which was unremarkable. Bone marrow biopsy showed morphologic changes suggestive of 5q-syndrome and cytogenetic examination was recommended. It revealed a 46, XX, del (5)(q13q33)karyotype and confirmed the diagnosis. During the 4-year follow-up there were no major changes in laboratory findings: a mild macrocytic anemia with variable elevation of platelet count and normal leukocyte count persisted. The patient was treated with packed red blood cell transfusions.
It was not necessary to add the material to the shelf.
Bibliographic material was successfully added on shelf.
Adding bibliographical material on shelf was not successful.
Material is already on the shelf.
Permalink
URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year
Impact factor
Edition
Category
Classification
JCR
SNIP
JCR
SNIP
JCR
SNIP
JCR
SNIP
Select the library membership card:
DRS,
in which the journal is indexed
Database name
Field
Year
Links to authors' personal bibliographies
Links to information on researchers in the SICRIS system
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
