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Kakovost blastocist in vitro in večplodna nosečnost = Quality of blastocyst in vitro and multiple pregnanciesKovačič, Borut ; Čižek-Sajko, Mojca ; Vlaisavljević, VeljkoIzhodišča. Blastociste, ki jih dobimo v postopku oploditve z biomedicinsko pomočjo (OBMP), imajo različne morfološke značilnosti. Namen raziskave je ugotoviti, kako morfologija blastocist, prenesenih ... v maternico, vpliva na zanositev in večplodno zanositev. Metode. Kakovost blastocist smo ocenjevali s štirimi parametri: deležem zarodka, preoblikovanega v blastocisto, razširjenostjo blastocela, obliko notranje skupine celic in z razrastjo celic trofektoderma. V prvo skupino smo uvrstili blastociste, ki so imele optimalne vse parametre, v drugo skupino blastociste z enim neoptimalnim parametrom in v tretjo skupino blastociste z več neoptimalnimi parametri. Retrospektivno smo analizirali rezultate 175 prenosov dveh blastocist iz prve skupine, 65 prenosov dveh blastocist iz druge skupine in 20 prenosov dveh blastocist iz tretje skupine. Rezultati. Delež blastocist, ki so se ugnezdile v maternici, je bil najvišji v prvi skupini in se je statistično značilno razlikoval v primerjavi z drugo in tretjo skupino (54,7% oz. 31,5% oz. 7,5%; p<0.05). Po prenosu dveh optimalnih blastocist smo v primerjavi z ostalima skupinama dosegli največ zanositev (62,3% oz. 40% oz. 15%; p<0,05). Delež večplodnih nosečnosti je bil v prvi skupini 56,9%, v drugi 23%, v tretji skupini pa večplodne nosečnosti ni bilo. Zaključki. Pri izboru blastocist za prenos v maternico je koristno upoštevati njihove morfološke značilnosti. Z našo ocenjevalno lestvico je možno izbrati blastociste z najvišjo kakovostjo. Ker je pri njih verjetnost ugnezditve več kot 50%, lahko brez tveganja vrnemo samo eno takšno blastocisto in se izognemo večplodnim nosečnostim.Source: Zbornik referatov (Str. II-89 - II-92)Type of material - conference contribution ; adult, seriousPublish date - 2003Language - slovenianCOBISS.SI-ID - 1310015
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Database name | Field | Year |
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Kovačič, Borut | 11040 |
Čižek-Sajko, Mojca | 20134 |
Vlaisavljević, Veljko | 08996 |
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