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A validation of discrete-element model simulations for predicting tablet coating variabilitySivanesapillai, Rakulan ...Achieving an even coating distribution on tablets during the coating process can be challenging, not to mention the challenges of accurately measuring and quantifying inter-tablet coating ... variability. Computer simulations using the Discrete Element Method (DEM) provide a viable pathway towards model-predictive design of coating processes. The purpose of this study was to assess their predictivity accounting for both experimental and simulation input uncertainties. To this end, a comprehensive set of coating experiments covering various process scales, process conditions and tablet shapes were conducted. A water-soluble formulation was developed to enable rapid spectroscopic UV/VIS analysis of coating amounts on a large number of tablets. DEM predictions are found to lie within the experimentally inferred confidence intervals in all cases. A mean absolute comparison error of 0.54 % was found between model predictions of coating variability and respective sample point estimates. Among all simulation inputs the parameterization of spray area sizes is considered the most significant source for prediction errors. However, this error was found significantly smaller in magnitude compared to experimental uncertainties at larger process scales underlining the value of DEM in the design of industrial coating processes.Source: International journal of pharmaceutics. - ISSN 0378-5173 (Vol. 624, art. 123109, art. 123109, 2023, 8 str.)Type of material - article, component part ; adult, seriousPublish date - 2023Language - englishCOBISS.SI-ID - 154966787
Author
Sivanesapillai, Rakulan |
Ehrig, Anja |
Nogueira White, Leon |
Vukosavljevic, Branko |
Grilc, Blaž, farmacevt |
German Ilić, Ilija, farmacevt |
Bharadwaj, Rahul |
Šibanc, Rok
Topics
Zdravila |
Farmacevtske oblike |
tablet film coating |
coating variability |
DEM simulation |
model-based process design |
filmska prevleka za tablete |
spremenljivost prevleke |
DEM simulacija |
načrtovanje procesa na osnovi modela |
metoda diskretnih elementov
source: International journal of pharmaceutics. - ISSN 0378-5173 (Vol. 624, art. 123109, art. 123109, 2023, 8 str.)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Sivanesapillai, Rakulan | |
Ehrig, Anja | |
Nogueira White, Leon | |
Vukosavljevic, Branko | |
Grilc, Blaž, farmacevt | 51457 |
German Ilić, Ilija, farmacevt | 28446 |
Bharadwaj, Rahul | |
Šibanc, Rok | 29888 |
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