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Herpesviridae and atypical bacteria co-detections in lower respiratory tract samples of SARS-CoV-2-positive patients admitted to an intensive care unit [Elektronski vir]Grubelnik, Gašper ...Shortly after the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), cases of viral, bacterial, and fungal coinfections in hospitalized patients became evident. This ... retrospective study investigates the prevalence of multiple pathogen co-detections in 1472 lower respiratory tract (LRT) samples from 229 SARS-CoV-2-positive patients treated in the largest intensive care unit (ICU) in Slovenia. In addition to SARS-CoV-2, (rt)RT-PCR tests were used to detect cytomegalovirus (CMV), Epstein–Barr virus (EBV), herpes simplex virus 1 (HSV-1), herpes simplex virus 2 (HSV-2), varicella zoster virus (VZV), and atypical bacteria: Chlamydia pneumoniae, Mycoplasma pneumoniae and Legionella pneumophila/spp. At least one co-detection was observed in 89.1% of patients. EBV, HSV-1, and CMV were the most common, with 74.7%, 58.1%, and 38.0% of positive patients, respectively. The median detection time of EBV, HSV-1, and CMV after initial SARS-CoV-2 confirmation was 11 to 20 days. Bronchoalveolar lavage (BAL) and tracheal aspirate (TA) samples showed equivalent performance for the detection of EBV, CMV, and HSV-1 in patients with both available samples. Our results indicate that SARS-CoV-2 infection could be a risk factor for latent herpesvirus reactivation, especially HSV-1, EBV, and CMV. However, additional studies are needed to elucidate the clinical importance of these findings.Source: Microorganisms [Elektronski vir]. - ISSN 2076-2607 (Vol. 12, iss. 4, [article no.] 714, 2024, str. 1-14)Type of material - e-article ; adult, seriousPublish date - 2024Language - englishCOBISS.SI-ID - 192370691
Author
Grubelnik, Gašper |
Korva, Miša |
Kogoj, Rok |
Polanc, Tina, mikrobiologinja |
Mavrič, Matej, medicina |
Jevšnik Virant, Monika |
Uršič, Tina, 1980- |
Keše, Darja, 1959- |
Seme, Katja, 1966- |
Petrovec, Miroslav |
Jereb, Matjaž, 1961- |
Avšič-Županc, Tatjana
Topics
SARS-CoV-2 |
co-detections |
coinfections |
lower respiratory tract |
ICU |
herpesviruses |
atypical bacteria |
SARS-CoV-2 |
soodkrivanje |
sočasne okužbe |
spodnji dihalni trakt |
herpesvirusi |
atipične bakterije
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Grubelnik, Gašper | 39128 |
Korva, Miša | 30696 |
Kogoj, Rok | 29937 |
Polanc, Tina, mikrobiologinja | ![]() |
Mavrič, Matej, medicina | 39764 |
Jevšnik Virant, Monika | 29997 |
Uršič, Tina, 1980- | 25433 |
Keše, Darja, 1959- | 05381 |
Seme, Katja, 1966- | 14504 |
Petrovec, Miroslav | 15902 |
Jereb, Matjaž, 1961- | 13300 |
Avšič-Županc, Tatjana | 10331 |
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