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Biološka zdravila za zdravljenje multiple skleroze = Biologicals for the treatment of multiple sclerosisBratkovič, Tomaž, farmacevt, 1978-Multipla skleroza je neozdravljiva nevrodegenerativna bolezen, za katero je značilna demielinizacija in propadanje nevronov, kar vodi v invalidnost. Z zgodnjim odkrivanjem in takojšnjim neprekinjenim ... zdrav - ljenjem s sodobnimi zdravili, med katera sodijo tudi biološka zdravila, lahko spremenimo potek bolezni – zmanjšamo pogostost in jakost zagonov ter omejimo kopičenje demielinizacijskih plakov v centralnem živčevju, s čimer upočasnimo napredovanje bolezni. V prispevku povzemamo izsledke kliničnih vrednotenj učinkovitosti in varnosti bioloških zdravil za zdravljenje multiple skleroze. Zlasti monoklonska protitelesa (natalizumab, alemtuzumab, ofatumumab, okrelizumab in ublituksimab) izkazujejo visoko učinkovitost, a jih povezujemo z nekaterimi resnimi neželenimi učinki, kot so sindrom sproščanja citokinov, (oportunistične) okužbe in avtoimunske bolezni.Source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 75, št. 2, 2024, str. 120-129)Type of material - article, component part ; adult, seriousPublish date - 2024Language - slovenianCOBISS.SI-ID - 196220163
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source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 75, št. 2, 2024, str. 120-129)
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Bratkovič, Tomaž, farmacevt, 1978- | 23598 |
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