Biološka zdravila za zdravljenje multiple skleroze = Biologicals for the treatment of multiple sclerosis
Bratkovič, Tomaž, farmacevt, 1978-
Multipla skleroza je neozdravljiva nevrodegenerativna bolezen, za katero je značilna demielinizacija in propadanje nevronov, kar vodi v invalidnost. Z zgodnjim odkrivanjem in takojšnjim neprekinjenim ...zdrav - ljenjem s sodobnimi zdravili, med katera sodijo tudi biološka zdravila, lahko spremenimo potek bolezni – zmanjšamo pogostost in jakost zagonov ter omejimo kopičenje demielinizacijskih plakov v centralnem živčevju, s čimer upočasnimo napredovanje bolezni. V prispevku povzemamo izsledke kliničnih vrednotenj učinkovitosti in varnosti bioloških zdravil za zdravljenje multiple skleroze. Zlasti monoklonska protitelesa (natalizumab, alemtuzumab, ofatumumab, okrelizumab in ublituksimab) izkazujejo visoko učinkovitost, a jih povezujemo z nekaterimi resnimi neželenimi učinki, kot so sindrom sproščanja citokinov, (oportunistične) okužbe in avtoimunske bolezni.
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