Mehanizmi delovanja osteoporotičnih zdravil ter klinična pričakovanja = Mechanisms of action of antiosteoporotic drugs and clinical expectations
Preželj, Janez
Throughout life, the skeleton undergoes constant renewal maintained by a constant cycle of bone resorption and formation. The imbalance between bone resorption and bone formation leads to bone loss ...and increased risk of fracture - osteoporosis. The therapeutic agents used in the treatment of osteoporosis all affect these processes. The majority of antiosteoporotic drugs used are antiresorptive, slowing or reversing bone loss. The only bone-forming agent available is teriparatide. Recently, a new drug combining antiresorptive and bone forming properties has been launched. By means of current therapies for osteoporosis we now are able to reduce the risk of fractures by approximately 50%. The treatment prescribed will depend on the patient's fracture risk, potential side effects, costs and the balance of efficacy and safety of the drug.
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