Področno preprečevanje strjevanja krvi s citratom med hemodializo : primerjava dializne raztopine z in brez kalcija : (magistrska naloga)
Černe, Senka
Effective anticoagulation with unfractionated heparin or low molecular heparinduring hemodialysis procedure is important for efficient and successfuldialysis. However, if heparin is contraindicated ...(risk of bleeding, HIT-heparin-induced thrombocytopenia), regional curate anticoagulation provides safe prevention of blood clotting in dialysis circuit without causingsystemic anticoagulation. In a prospective randomized clinical study wehave compared the efficacy and safety of two protocols for regional anticogulation with trisodium citrate using calcium free dialysate and dialysate with calcium 1,25 mmol/l. In our study we enrolled patients older than 18 years with end stage renal disease, in whom we have already performed regional citrate anticoagulation with 4% solution of trisodium citrate withoutany complications. 50 hemodialysis procedures were randomly assigned (25 to each group) to calcium-free dialysate or calcium containing dialysate (1,25 mmol/l) both with Mg 0,5 mmol/l, lowered concentrations of sodium (138 mmol/l) and bicarbonate (28 mmol/l). We performed regional anticoagulation with infusion of 15% trisodium citrate and 1M CaCl2. The efficiency of anticoagulation was assessed using hour-glass clotting time, measuring concentration of ionised calcium after citrate infusion in dialysis circuit, measuring the volume of clots in arterial or venous bubble trap and counting the number of clotted capillaries in dialyser. The scoring system for evaluation of anticoagulation in the dialyser and arterial and venous bubble trap was ranged from 1 (complete clotting) to 5 (the best, no clotting). During the treatment we monitored the concentrations of ionized calcium, sodium, pH and bicarbonate. Using calcium free dialysate our results showed very good anticoagulation score for both bubble traps (arterial 4,7 +- 0,5 andvenous 4,8 +- 0,6) and dialyzer (4,5 +- 0,6). (Abstract truncated at 2000 characters)
Type of material - master's thesis
; adult, serious
Publication and manufacture - [Ljubljana : S. Černe], 2007
It was not necessary to add the material to the shelf.
Bibliographic material was successfully added on shelf.
Adding bibliographical material on shelf was not successful.
Material is already on the shelf.
Permalink
URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year
Impact factor
Edition
Category
Classification
JCR
SNIP
JCR
SNIP
JCR
SNIP
JCR
SNIP
Select the library membership card:
DRS,
in which the journal is indexed
Database name
Field
Year
Links to authors' personal bibliographies
Links to information on researchers in the SICRIS system
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
