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Common and specific large-scale brain changes in major depressive disorder, anxiety disorders, and chronic pain : a transdiagnostic multimodal meta-analysis of structural and functional MRI studiesBrandl, Felix ...Major depressive disorder (MDD), anxiety disorders (ANX), and chronic pain (CP) are closely-related disorders with both high degrees of comorbidity among them and shared risk factors. Considering ... this multi-level overlap, but also the distinct phenotypes of the disorders, we hypothesized both common and disorder-specific changes of large-scale brain systems, which mediate neural mechanisms and impaired behavioral traits, in MDD, ANX, and CP. To identify such common and disorder-specific brain changes, we conducted a transdiagnostic, multimodal meta-analysis of structural and functional MRI-studies investigating changes of gray matter volume (GMV) and intrinsic functional connectivity (iFC) of large-scale intrinsic brain networks across MDD, ANX, and CP. The study was preregistered at PROSPERO (CRD42019119709). 320 studies comprising 10,931 patients and 11,135 healthy controls were included. Across disorders, common changes focused on GMV-decrease in insular and medial-prefrontal cortices, located mainly within the so-called default-mode and salience networks. Disorder-specific changes comprised hyperconnectivity between defaultmode and frontoparietal networks and hypoconnectivity between limbic and salience networks in MDD; limbic network hyperconnectivity and GMV-decrease in insular and medial-temporal cortices in ANX; and hypoconnectivity between salience and default-mode networks and GMV-increase in medial temporal lobes in CP. Common changes suggested a neural correlate for comorbidity and possibly shared neuro-behavioral chronification mechanisms. Disorder-specific changes might underlie distinct phenotypes and possibly additional disorder-specific mechanisms.Source: Neuropsychopharmacology. - ISSN 0893-133X (47, 2022, str. 1071-1080)Type of material - article, component partPublish date - 2022Language - englishCOBISS.SI-ID - 102554115
Author
Brandl, Felix |
Weise, Benedikt |
Mulej Bratec, Satja |
Jassim, Nazia |
Hoffmann Ayala, Daniel |
Bertram, Teresa |
Ploner, Markus |
Sorg, Christian
Topics
človeško vedenje ob nevarnosti |
velika depresivna motnja |
kronična bolečina |
strukturni fMR |
funkcijski fMR |
ne zaključna dela |
human threat behaviour |
major depressive disorder |
anxiety disorders |
chronic pain |
structural MRI |
functional MRI
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Brandl, Felix | ![]() |
Weise, Benedikt | ![]() |
Mulej Bratec, Satja | 54046 |
Jassim, Nazia | ![]() |
Hoffmann Ayala, Daniel | ![]() |
Bertram, Teresa | ![]() |
Ploner, Markus | ![]() |
Sorg, Christian | ![]() |
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