(UM)
-
Simulacija vpliva različnih inhibitorjev encima fosfodiesteraze 5 na produkcijo cikličnega gvanozin monofosfata : diplomski seminar na študijskem programu 1. stopnje FizikaMeštrović, KatarinaV diplomskem seminarju preučujemo vpliv inhibitorjev encima fosfodiesteraze 5 (PDE5) na produkcijo cikličnega gvanozin monofosfata (cGMP). S fizikalno-matematičnim modelom za sintezo in razgradnjo ... cGMP simuliramo vpliv štirih inhibitorjev PDE5 (sildenafil, vardenafil, tadalafil in avanafil), tako da že obstoječ model nadgradimo s farmakokinetičnim modelom oralne aplikacije inhibitorjev PDE5. S tem modelom napovemo, kako inhibitorji PDE5 vplivajo na molarno koncentracijo cGMP v gladki mišični celici v odvisnosti od časa. Rezultati modela kažejo, da ima avanafil zaradi svojih farmakokinetičnih lastnosti in močnega inhibitornega učinka na encim PDE5 tudi največji vpliv na koncentracijo cGMP v gladki mišični celici. Iz simulacij ugotovimo, da ima kombinacija inhibitorjev PDE5 s konstantnim dotokom dušikovega oksida (NO) najmočnejši vpliv na povišano produkcijo cGMP, kar vodi do relaksacije žilnih sten.Type of material - undergraduate thesis ; adult, seriousPublication and manufacture - Maribor : [K. Meštrović], 2022Language - slovenianCOBISS.SI-ID - 127245571
Author
Meštrović, Katarina
Other authors
Fajmut, Aleš
Topics
gladka mišična celica |
dušikov oksid |
ciklični gvanozin monofosfat |
fosfodiesteraza |
diplomski seminarji |
smooth muscle cell |
nitric oxide |
cyclic guanosine monophosphate |
phosphodiesterase
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Library | Call number – location, accession no. ... | Copy status |
---|---|---|
Miklošič Library FPNM, Maribor | D DIPL 53 MEŠTROVIĆ K. Simulacija IN: 920220035 |
available - reading room |
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Meštrović, Katarina | ![]() |
Fajmut, Aleš | 19553 |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location: