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Regulatory T-cells in periapical lesionsČolić, Miodrag ...CD4+CD25hiFoxp3+ regulatory T-cells (Tregs) are of crucial importance in regulating the immune response, including the control of any defense against infection. Their presence in periapical lesions ... has not been demonstrated, as yet. We hypothesized that Tregs infiltrate periapical lesions, where they inhibit T-cell proliferation. The aim of this study was to characterize Tregs in periapical lesions by confocal microscopy, flow cytometry, and functional assays. We showed that CD4+CD25hiFoxp3+ cells in periapical lesions expressed IL-10 and TGF-â. Their frequency was significantly higher than in peripheral blood and correlated with the levels of TGF-â and IL-10 in culture supernatants of periapical lesion mononuclear cells. Tregs inhibited the proliferation of responder T-cells in vitro, at least in part, by stimulating the production of IL-10. These findings suggest that CD4+CD25hiFoxp3+ cells inperiapical lesions may play regulatory roles in controlling local immune/ inflammatory processes.Source: Journal of dental research. - ISSN 0022-0345 (Vol. 88, no. 11, Nov. 2009, str. 997-1002)Type of material - article, component partPublish date - 2009Language - englishCOBISS.SI-ID - 13523734
Author
Čolić, Miodrag |
Gazivoda, Dragan |
Vučević, Dragana |
Majstorović, I. |
Vasilijić, Saša |
Rudolf, Rebeka |
Brkić, Z. |
Milosavljević, P.
Topics
medicina |
periapikalna rana |
citokini |
celična kultura |
pretočna citometrija |
konfokalna mikroskopija |
T-celica |
kontrola lokalnih vnetnih procesov |
imunski odziv |
periapical lesion |
immune response |
local immune processes control |
flow cytometry |
confocal microscopy |
cell culture |
cytokine |
regulatory T-cells
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Čolić, Miodrag | |
Gazivoda, Dragan | |
Vučević, Dragana | |
Majstorović, I. | |
Vasilijić, Saša | |
Rudolf, Rebeka | 14335 |
Brkić, Z. | |
Milosavljević, P. |
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