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Importance of cell variability for calcium signaling in rat airway myocytesMarhl, Marko ...Calcium signaling controls several essential physiological functions in different cell types. Hence, it is not surprising that different aspects of Ca2+ dynamics are in the focus of in-depth and ... extensive investigations. Efforts concentrate on the development of proper theoretical models that would provide a unified description of Ca2+ signaling. Remarkably, experimentally recorded Ca2+ signals exhibit a rather large diversity, which can be observed irrespective of the cell type, measuring techniques, or the nature of the signal. Our goal in the present study therefore is to present a theoretical explanation for the variability observed in experiments, whereby we focus on caffeine-induced Ca2+ responses in isolated airway myocytes. By employing a stochastic model, we first test whether the observed variability can be attributed to intrinsic fluctuations that are a common feature of biochemical reactions that govern Ca2+ signalization. We find that stochastic effects, within ranges that correspond to actual conditions in the cell, are far too modest to explain the large diversity observed in experimental data. Foremost, we reveal that only cell variability in theoretical modeling can appropriately describe the observed diversity in single-cell responses.Source: Biophysical chemistry. - ISSN 0301-4622 (Vol. 148, iss. 1/3, 2010, str. 42-50)Type of material - article, component partPublish date - 2010Language - englishCOBISS.SI-ID - 14070550
Author
Marhl, Marko |
Gosak, Marko, 1982- |
Perc, Matjaž |
Roux, Etienne
Topics
kalcijeva signalizacija |
dihalne gladke mišične celice |
stohastični efekti |
celična variabilnost |
senzitivnostna analiza |
calcium signaling |
airway smooth muscle cell |
stochastic effects |
cell variability |
sensitivity analysis
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Marhl, Marko | 13159 |
Gosak, Marko, 1982- | 28405 |
Perc, Matjaž | 23428 |
Roux, Etienne | ![]() |
Source: Personal bibliographies
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