Heparin adsorption onto model poly(ethylene terephtalate) (PET) surfaces monitored by QCM-D; Spremljanje adsorpcije heparina na modelne polietilentereftalatne (PET) površine s pomočjo kremenove mikrotehtnice

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Heparin adsorption onto model poly(ethylene terephtalate) (PET) surfaces monitored by QCM-D = Spremljanje adsorpcije heparina na modelne polietilentereftalatne (PET) površine s pomočjo kremenove mikrotehtnice

Doliška, Aleš ; Strnad, Simona, 1965- ; Stana-Kleinschek, Karin

The adsorption of anticoagulant heparin onto model poly(ethylene terephtalate) (PET) film was monitored using a quartz crystal microbalance with a dissipation unit (QCM-D). Synthetic vascular grafts ... are usually made from PET, a material with appropriate mechanical properties but moderate haemocompatibility. Therefore anticoagulant heparin is usually used to improve haemocompatibility of PET surfaces. Heparin possesses a high negative charge and as such does not adsorb directly onto hydrophobic PET, which is also negatively charged. To increase heparin adsorption different cationic polymers were investigated as spacers and the highest adsorption was achieved using polyethyleneimine (PEI) as an anchoring agent. The heparin was adsorbed from water solution as well as from phosphate buffer saline (PBS). Heparin dissolved in PBS adsorb better onto PET than heparin from water solution. The results were characterized using Sauerbrey equation and Voigt based viscoelastic model. We found out that heparin adsorbed onto PET formed a thin and rigid film and that Sauerbrey equation is appropriate for characterization of heparin adsorption onto PET.

Source: Materiali in tehnologije = Materials and technology. - ISSN 1580-2949 (Letn. 46, št. 1, jan.-feb. 2012, str. 81-85)

Type of material - article, component part

Publish date - 2012

Language - english

COBISS.SI-ID - 15775766

Link(s):
http://mit.imt.si/Revija/izvodi/mit121/doliska.pdf
Digital Library of the University of Maribor – DLUM
Digitalna knjižnica Slovenije - dLib.si

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Doliška, Aleš | Strnad, Simona, 1965- | Stana-Kleinschek, Karin

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source: Materiali in tehnologije = Materials and technology. - ISSN 1580-2949 (Letn. 46, št. 1, jan.-feb. 2012, str. 81-85)

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Year	Impact factor		Edition		Category		Classification
Year	JCR	SNIP	JCR	SNIP	JCR	SNIP	JCR	SNIP

Links to authors' personal bibliographies	Links to information on researchers in the SICRIS system
Doliška, Aleš	17577
Strnad, Simona, 1965-	10575
Stana-Kleinschek, Karin	07814

Source: Personal bibliographies and: SICRIS

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