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  • Design of simultaneous antimicrobial and anticoagulant surfaces based on nanoparticles and polysaccharides
    Breitwieser, Doris ...
    The rational design of silver nanoparticles encapsulated in an anticoagulant, hemocompatible polysaccharide, 6-O-chitosan sulfate, is presented. Three different approaches are described for the ... immobilization of these core shell particles on cellulosic surfaces. The mass of the immobilized particles is quantified using a quartz crystal microbalance with dissipation (QCM-D). The antimicrobial activity of the surfaces towards E.coli MG 1655 [R1-16] is investigated in dependence of the immobilization method by live/dead assays using fluorescence staining. All surfaces treated with the designed nanoparticles exhibit excellent antimicrobial activity towards E.coli MG 1655 [R1-16]. Anticoagulant properties of blood plasma on the nanoparticle treated surfaces have been determined using QCM-D. In comparison to the unmodified substrates, the total coagulation time as well as the thrombin formation time and fibrin clotting time of surfaces modified with nanoparticles are significantly increased.
    Source: Journal of materials chemistry. B, Materials for biology and medicine. - ISSN 2050-750X (Vol. 2013, iss. 15, 2013, str. 2022-2030)
    Type of material - article, component part
    Publish date - 2013
    Language - english
    COBISS.SI-ID - 16670742
    DOI

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