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Synthesis, purification, and cell-toxicity of a choline betainate [Elektronski vir]Jurko, Lucija ...In this work, choline chloride and betaine hydrochloride were condensed into a - to our knowledge - unreported choline betainate (N,N,N-trimethyl-2-oxo-2-(2-(trimethylammonio)ethoxy)ethanaminium ... chloride) using 1,1′-carbonyldiimidazole (CDI) activation of betaine hydrochloride in dimethylsulfoxide. The product and reaction intermediates were isolated, purified by preparative HPLC and analyzed in detail by infrared and nuclear magnetic resonance spectroscopy. The final product has a high cytotoxicity for L929 mouse fibroblasts, and low antibacterial activity against P. Aeruginosa and S. Aureus at concentrations of up to 20 mg/ml. It could potentially further be investigated for similar uses as suxamethonium chloride, a muscle relaxant drug.Source: Journal of molecular structure [Elektronski vir]. - ISSN 1872-8014 ([article no.] 138581, Available online 8 May 2024, [16] str.)Type of material - e-article ; adult, seriousPublish date - 2024Language - englishCOBISS.SI-ID - 195589379
Author
Jurko, Lucija |
Hostnik, Gregor |
Steindorfer, Tobias Alexander |
Štern, Alja |
Bošković, Perica |
Bračič, Matej, 1981- |
Žegura, Bojana |
Kargl, Rupert
Topics
molekularna biologija |
holin klorid |
betain hidroklorid |
karbonildiimidazol |
protimikrobnost |
cititoksičnost |
choline chloride |
betaine hydrochloride |
carbonyldiimidazole |
HPLC |
antimicrobial |
cytotoxicity
Shelf entry
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| Database name | Field | Year |
|---|
| Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
|---|---|
| Jurko, Lucija | 52326 |
| Hostnik, Gregor | 34351 |
| Steindorfer, Tobias Alexander |  |
| Štern, Alja | 32094 |
| Bošković, Perica | |
| Bračič, Matej, 1981- | 37632 |
| Žegura, Bojana | 20767 |
| Kargl, Rupert | 36303 |
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