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Vpliv antiglavkomske terapije na izražanje antigenov HLA-DR na epitelijskih celicah veznice : doktorska naloga = The influence of antiglaucoma therapy on the expression of HLA-DR antigens on conjunctival epithelial cells : doctoral thesisCvenkel, BarbaraPurpose: To analyse the expression of inflammatory markers HLA-DR on conjunctival epithelial cells in patients taking topical antiglaucoma therapy. Methods: The impression cytology specimens were ... obtained from 10 patients taking no topical medication and from 39 patients with uncontrolled glaucoma referred for filtration surgery. In none of the patients was an ocular surface inflammation present as evaluated by slit lamp examination, tear break up time, and Schirmer's test. The specimens were collected preoperatively, 3 months, and 6 months after surgery. The expression of HLA-DRon T lymphocytes and epitheliai cells was analysed by flow cytometry. Results: A significant increase in the level of HLA-DR fluorescence on epithelial cells was found preoperatively in patients with glaucoma compared to control group (P = 0,002). Antiglaucoma therapy for three months or more with at least two topical medications induced significant subclinical inflammation which persisted regardless of the duration of therapy. The increased percentage of HLA-DR positive epithelial cells and T lymphocytes in the control group (P = 0,006 and P = 0,01) mainly reflected the greater numberof collected cells, and not the level of inflammation. A significant increased expression of HLA-DR on T lymphocytes was detected 3 months after surgery (P = 0,04). Higher percentage and fluorescence intensity of reactive T lymphocytes was associated with higher percentage and fluorescence intensity of reactive epithelial cells three months after surgery. Six months after surgery the level of HLA-DR fluorescence on epithelial cells and T lymphocytesdecreased but remained elevated versus preoperative levels. (Abstract truncated at 2000 characters)Type of material - dissertation ; adult, seriousPublication and manufacture - Ljubljana : [B. Cvenkel], 2001Language - slovenianCOBISS.SI-ID - 2288916
Author
Cvenkel, Barbara
Other authors
Ihan, Alojz |
Stirn-Kranjc, Branka
Topics
Glaucoma |
Immunology |
Conjunctiva |
Immunology |
HLA-DR antigens |
Diagnostic use |
Glaucoma |
Drug therapy |
Glavkom |
Imunologija |
Veznica |
Imunologija |
HLA-DR antigeni |
Diagnostična raba |
Glavkom |
Terapija z zdravili |
Glavkom |
Zdravljenje |
Disertacije |
oftalmologija |
očesni tlak |
farmakoterapija |
kirurško zdravljenje |
očesna veznica |
imunologija |
antigeni |
pretočna citometrija
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University of Maribor Library | Skladišče II 52392 | available - reading room |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Cvenkel, Barbara | 21069 |
Ihan, Alojz | 10337 |
Stirn-Kranjc, Branka | 09156 |
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