Variabilnost elektrokardiograma po presaditvi srca : doktorsko delo

(UM)

Variabilnost elektrokardiograma po presaditvi srca : doktorsko delo

Samarin Lovrič, Silvia

Objective: During the heart transplantation procedure, allograft becomes completely denervated. Partial ventricular sympathetic reinnervation may develop one year or later after the transplantation ... and is of functional significance. The relation between sinus node sympathetic reinnervation and left ventricular sympathetic reinnervation is not known. Aim of our study was to assess sympathetic reinnervation of sinus node and left ventricle and to evaluate their time dependence. MethodsČ Two independent non-invasive methods were usedČ sympathetic reinnervation was evaluated with RR interval variability analysis and left ventricular sympathetic reinnervation was evaluated with iodine-123-meta-iodobenziylguanidine (123-IMIBG) scintigraphy. Twelve patients and 14 healthy controls were studied. Bipolar ECG with high sampling rate and resolution was recorded over 8.5 minutes in supine and in upright position. RR intervals in time domain and in frequency domain were analysed to evaluate sinus node reinnervation. Spectral power in low frequency(LF) range (0.04-O.15Hz) above 4.5 ms2 was considered as sinus node sympathetic reinnervation. Patients were divided in groups with sinus node sympathetic reinnervation (LF>4.5 ms2) and without sinus node sympathetic reinnervation (LF<4.5 ms2). In patients, 123-I-MIBG scintigraphy was performed. Heart to mediastinum ratio (HMR) was calculated and patients were divided in groups with left ventricular reinnervation (HMR>1.3) and without left ventricular reinnervation (HMR<1.3). The results of both methods were compared and the coexistence of sinus node sympathetic reinnervation and left ventricular sympathetic reinnervation was evaluated. Blood sample for plasma catecholamine levels was taken in supine body position in patients, just before 123-I-MIBG injection. (Abstract truncated at 2000 characters)

Type of material - dissertation

Publication and manufacture - Ljubljana : [S. Samarin Lovrič], 2005

Language - slovenian

COBISS.SI-ID - 2800404

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Rakovec, Peter | Milčinski, Metka

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Library	Call number – location, accession no. ...	Copy status
University of Maribor Library	Skladišče II 60512	available - reading room

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Year	Impact factor		Edition		Category		Classification
Year	JCR	SNIP	JCR	SNIP	JCR	SNIP	JCR	SNIP

Links to authors' personal bibliographies	Links to information on researchers in the SICRIS system
Samarin Lovrič, Silvia	20713
Rakovec, Peter	09160
Milčinski, Metka	09070

Source: Personal bibliographies and: SICRIS

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