Uravnavanje fibrinolitične aktivnosti krvi : vloga maščevja : doktorska disertacija
Mavri, Alenka
Impaired fibrinolysis, due to elevated levels of plasminogen activator inhibitor-1(PAI-1) is associated with increased risk of cardiovascular diseases. Excess of circulating PAI-1 may influence ...fibrin degradation and also directly influence vessel wall remodelling. In obesity levels of PAI-1 are increased and could account for high risk of cardiovascular disease in obese individuals. The mechanisms involved in increased PAI-1 production in obesity are far from being explained. Therefore, the aim of our studies was toelucidate the role of adipose tissue in plasma PAI-1 regulation. In the first 3 studies, plasma PAI-1, adipsin, leptin, insulin, lipoproteins and fibrinogen were determined in obese women before and after weight reduction program and after 5 months of follow up. Furthermore, intima-media thickness was measured at entry and after followup. In the fourth study, PAI-1 expression in abdominal and femoral subcutaneous fat was studied before and after weight reduction. Our studies showed that the decrease in PAI-1 after weight reduction was more closely related to adipose tissue changes, than to changes in metabolic variables. We found that relatively low serum leptin levels might be predictive for weight regain after successful weight reduction. By studying the extent of carotid atherosclerosis, we found that early atherosclerotic changes may be reversed by normalisation of body weight and its long-term maintenance. The fourth study showed that PAI-I expression is increased in abdominal, but not in femoral subcutaneous fat of obese subjects. However, after weight reduction the decrease in PAI-1 mRNA content in abdominal subcutaneous fat was not assoviated with decrease in plasma PAI-1. (Abstract truncated at 2000 characters).
Type of material - dissertation
; adult, serious
Publication and manufacture - Ljubljana : [A. Mavri], 2001
It was not necessary to add the material to the shelf.
Bibliographic material was successfully added on shelf.
Adding bibliographical material on shelf was not successful.
Material is already on the shelf.
Permalink
URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year
Impact factor
Edition
Category
Classification
JCR
SNIP
JCR
SNIP
JCR
SNIP
JCR
SNIP
Select the library membership card:
DRS,
in which the journal is indexed
Database name
Field
Year
Links to authors' personal bibliographies
Links to information on researchers in the SICRIS system
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
