Študij fluidnosti celičnih membran pljučnega raka z elektronsko paramagnetno resonanco = Cell membrane fluidity in lung cancer studied by electron paramagnetic resonance : doktorsko delo
Sok, Mihael
Cancer cells generally have more fluid cell membranes than non-cancer cells. The fluidity of cell membranes can be measured and investigated by electron paramagnetic resonance (EPR) following the ...incorporation of a spin label into the cell membrane. In a prospective study, we evaluated the fluidity of cell membranes in tissue specimens of lung cancer removed during pulmonary resection. Methylester of 5-doxyl palmitate (MeFASL - 10.3) was used as the spin probe. The EPR parameter H13 served as the measure of membrane fluidity. A greater H13 value indicated a more fluid environment or a greater proportionof cells having more fluid membranes. On the basis of operative findings and results of histologic examination, the stage of lung cancer was determined. The proportions of individual cell types (cancer cells, conective tissue cells, inflammatory cells, necrotic cells) in the sample were assessed by histopathologist. We wished to determine (a) whether lung cancer tissue hadgreater cell membrane fluidity than normal lung tissue, (b) whether different proportions of individual cell types affected the measured fluidity of cell membranes in tissue specimen, (c) whether the cell membrane fluidity in the resected lung cancer specimens was related to the patientćs survival after operation. The study covered 51 patients, who were devided into two groups according to the calculated value of H13. The limit value of H13 between two groups was 24. We found that cell membranes in lung cancer specimens were more fluid than cell membranes in normal lung tissue. (Abstracttruncated at 3200 characters).
Type of material - dissertation
Publication and manufacture - Ljubljana : [M. Sok], 1995
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