Inspection of heat sterilisation process in bio-reactor by temperature distribution measurement
Hribernik, Aleš, 1960- ...
Sterilisation of substratum by heat is commonly used in food industry and pharmacy. The idea is to heat up the substratum within the bio-reactor and to keep it at the specified sterilisation ...temperature as long as necessary to destroy all the micro-organisms presented in the substratum. The sterilisation temperature may not be exceeded, since the significant reduction of substratum quality occurs by overheating. Therefore, the temperature of substratum has to be controlled carefully during the sterilisation. Control of saturation pressure within bio-reactor is a successful method for overall temperature control. However, the spatial differences in temperature distribution may occur due to increased heat source (near heater) or heat sink (near reactor walls). ln order to study the spatial distribution of substratum temperature within a large bio-reactor the reactor vessel was instrumented by a number of thermocouples placed in all critical regions of reactor. Temperature measurement points were determined by a combination of infrared temperature measurement of bio-reactor outer walls for the prediction of near wall critical reactor regions, and by 3D flow simulation for the prediction of critical regions within the reactor. The results of the study are presented and discussed in the paper.
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