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Lee, Anthony G
Biophysical journal, 07/2020, Volume: 119, Issue: 1Journal Article
Inwardly rectifying, voltage-gated, two-pore domain, and related K channels are located in eukaryotic membranes rich in cholesterol. Here, molecular docking is used to detect specific binding sites ("hot spots") for cholesterol on K channels with characteristics that match those of known cholesterol binding sites. The transmembrane surfaces of all available high-resolution structures for K channels were swept for potential binding sites. Cholesterol poses were found to be located largely in hollows between protein ridges. A comparison between cholesterol poses and resolved phospholipids suggests that not all cholesterol molecules binding to the transmembrane surface of a K channel will result in displacement of a phospholipid molecule from the surface. Competition between cholesterol binding and binding of anionic phospholipids essential for activity could explain some of the effects of cholesterol on channel function.
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