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Rodrigues, Ivanildes V; Seibert, Janaina B; Carneiro, Simone P; de Souza, Gustavo H B; dos Santos, Orlando D H; Lopes, Norberto P
Current pharmaceutical biotechnology, 01/2013, Volume: 14, Issue: 15Journal Article
The triterpenes α- and β-amyrins display important pharmacological activities. As a result of their high hydrophobia, they present low water solubility and reflect poor oral bioavailability. Different techniques can be used for the improvement of amyrins solubility, one of them is the use of nanoemulsions. Therefore, the method of direct emulsification was used to develop a nanoemulsion of these triterpenes and the resulting drug delivery system was characterized by an in vitro release assay. Encapsulation efficiency higher than 99% was achieved with total release around 30% in 24 h, which suggests that this system could be useful for the administration of α- and β-amyrins by different routes in an efficient way.
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