Abstract Very massive stars (VMSs) formed via a sequence of stellar collisions in dense star clusters have been proposed as the progenitors of massive black hole seeds. VMSs could indeed collapse to form intermediate-mass black holes, which would then grow by accretion to become the supermassive black holes observed at the centers of galaxies and powering high-redshift quasars. Previous studies have investigated how different cluster initial conditions affect the formation of a VMS, including mass segregation, stellar collisions, and binaries, among others. In this study, we investigate the growth of VMSs with a new grid of Cluster Monte Carlo star cluster simulations—the most expansive to date. The simulations span a wide range of initial conditions, varying the number of stars, cluster density, stellar initial mass function (IMF), and primordial binary fraction. We find a gradual shift in the mass of the most massive collision product across the parameter space; in particular, denser clusters born with top-heavy IMFs provide strong collisional regimes that form VMSs with masses easily exceeding 1000 M ⊙ . Our results are used to derive a fitting formula that can predict the typical mass of a VMS formed as a function of the star cluster properties. Additionally, we study the stochasticity of this process and derive a statistical distribution for the mass of the VMS formed in one of our models, recomputing the model 50 times with different initial random seeds.