E-resources
Peer reviewed
-
Frank, Brandon; Ally, Madeline; Brekke, Bailee; Zetterberg, Henrik; Blennow, Kaj; Sugarman, Michael A; Ashton, Nicholas J; Karikari, Thomas K; Tripodis, Yorghos; Martin, Brett; Palmisano, Joseph N; Steinberg, Eric G; Simkina, Irene; Turk, Katherine W; Budson, Andrew E; O'Connor, Maureen K; Au, Rhoda; Goldstein, Lee E; Jun, Gyungah R; Kowall, Neil W; Stein, Thor D; McKee, Ann C; Killiany, Ronald; Qiu, Wei Qiao; Stern, Robert A; Mez, Jesse; Alosco, Michael L
Alzheimer's & dementia, 08/2022, Volume: 18, Issue: 8Journal Article
We examined the ability of plasma hyperphosphorylated tau (p-tau) to detect cognitive impairment due to Alzheimer's disease (AD) independently and in combination with plasma total tau (t-tau) and neurofilament light (NfL). Plasma samples were analyzed using the Simoa platform for 235 participants with normal cognition (NC), 181 with mild cognitive impairment due to AD (MCI), and 153 with AD dementia. Statistical approaches included multinomial regression and Gaussian graphical models (GGMs) to assess a network of plasma biomarkers, neuropsychological tests, and demographic variables. Plasma p-tau discriminated AD dementia from NC, but not MCI, and correlated with dementia severity and worse neuropsychological test performance. Plasma NfL similarly discriminated diagnostic groups. Unlike plasma NfL or t-tau, p-tau had a direct association with cognitive diagnosis in a bootstrapped GGM. These results support plasma p-tau for the detection of AD dementia and the use of blood-based biomarkers for optimal disease detection.
Author
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.