E-resources
-
Gerson, James N; Handorf, Elizabeth; Villa, Diego; Gerrie, Alina S; Chapani, Parv; Li, Shaoying; Medeiros, L Jeffrey; Wang, Michael I; Cohen, Jonathon B; Calzada, Oscar; Churnetski, Michael C; Hill, Brian T; Sawalha, Yazeed; Hernandez-Ilizaliturri, Francisco J; Kothari, Shalin; Vose, Julie M; Bast, Martin A; Fenske, Timothy S; Narayana Rao Gari, Swapna; Maddocks, Kami J; Bond, David; Bachanova, Veronika; Kolla, Bhaskar; Chavez, Julio; Shah, Bijal; Lansigan, Frederick; Burns, Timothy F; Donovan, Alexandra M; Wagner-Johnston, Nina; Messmer, Marcus; Mehta, Amitkumar; Anderson, Jennifer K; Reddy, Nishitha; Kovach, Alexandra E; Landsburg, Daniel J; Glenn, Martha; Inwards, David J; Karmali, Reem; Kaplan, Jason B; Caimi, Paolo F; Rajguru, Saurabh; Evens, Andrew; Klein, Andreas; Umyarova, Elvira; Pulluri, Bhargavi; Amengual, Jennifer E; Lue, Jennifer K; Diefenbach, Catherine; Fisher, Richard I; Barta, Stefan K
Journal of clinical oncology, 02/2019, Volume: 37, Issue: 6Journal Article
Mantle cell lymphoma (MCL) is a B-cell lymphoma characterized by cyclin D1 expression. Autologous hematopoietic cell transplantation (AHCT) consolidation after induction chemotherapy is often used for eligible patients; however, the benefit remains uncertain in the rituximab era. Herein we retrospectively assessed the impact of AHCT consolidation on survival in a large cohort of transplantation-eligible patients age 65 years or younger. We retrospectively studied transplantation-eligible adults age 65 years or younger with newly diagnosed MCL treated between 2000 and 2015. The primary objective was to assess for improved progression-free survival (PFS) with AHCT consolidation and secondarily to assess for improved overall survival (OS). Cox multivariable regression analysis and propensity score-weighted (PSW) analysis were performed. Data were collected from 25 medical centers for 1,254 patients; 1,029 met inclusion criteria. Median follow-up for the cohort was 76 months. Median PFS and OS were 62 and 139 months, respectively. On unadjusted analysis, AHCT was associated with improved PFS (75 v 44 months with v without AHCT, respectively; P < .01) and OS (147 v 115 months with v without AHCT, respectively; P < .05). On multivariable regression analysis, AHCT was associated with improved PFS (hazard ratio HR, 0.54; 95% CI, 0.44 to 0.66; P < .01) and a trend toward improved OS (HR, 0.77; 95% CI, 0.59 to 1.01; P = .06). After PSW analysis, AHCT remained associated with improved PFS (HR, 0.70; 95% CI, 0.59 to 0.84; P < .05) but not improved OS (HR, 0.87; 95% CI, 0.69 to 1.1; P = .2). In this large cohort of younger, transplantation-eligible patients with MCL, AHCT consolidation after induction was associated with significantly improved PFS but not OS after PSW analysis. Within the limitations of a retrospective analysis, our findings suggest that in younger, fit patients, AHCT consolidation may improve PFS.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.