E-resources
-
Schork, Andrew J; Won, Hyejung; Appadurai, Vivek; Nudel, Ron; Gandal, Mike; Delaneau, Olivier; Revsbech Christiansen, Malene; Hougaard, David M; Bækved-Hansen, Marie; Bybjerg-Grauholm, Jonas; Giørtz Pedersen, Marianne; Agerbo, Esben; Bøcker Pedersen, Carsten; Neale, Benjamin M; Daly, Mark J; Wray, Naomi R; Nordentoft, Merete; Mors, Ole; Børglum, Anders D; Bo Mortensen, Preben; Buil, Alfonso; Thompson, Wesley K; Geschwind, Daniel H; Werge, Thomas
Nature neuroscience, 03/2019, Volume: 22, Issue: 3Journal Article
There is mounting evidence that seemingly diverse psychiatric disorders share genetic etiology, but the biological substrates mediating this overlap are not well characterized. Here we leverage the unique Integrative Psychiatric Research Consortium (iPSYCH) study, a nationally representative cohort ascertained through clinical psychiatric diagnoses indicated in Danish national health registers. We confirm previous reports of individual and cross-disorder single-nucleotide polymorphism heritability for major psychiatric disorders and perform a cross-disorder genome-wide association study. We identify four novel genome-wide significant loci encompassing variants predicted to regulate genes expressed in radial glia and interneurons in the developing neocortex during mid-gestation. This epoch is supported by partitioning cross-disorder single-nucleotide polymorphism heritability, which is enriched at regulatory chromatin active during fetal neurodevelopment. These findings suggest that dysregulation of genes that direct neurodevelopment by common genetic variants may result in general liability for many later psychiatric outcomes.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.