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Deshmukh, Harshal; Wilmot, Emma G; Gregory, Robert; Barnes, Dennis; Narendran, Parth; Saunders, Simon; Furlong, Niall; Kamaruddin, Shafie; Banatwalla, Rumaisa; Herring, Roselle; Kilvert, Anne; Patmore, Jane; Walton, Chris; Ryder, Robert E J; Sathyapalan, Thozhukat
Diabetes care, 09/2020, Volume: 43, Issue: 9Journal Article
The FreeStyle Libre (FSL) flash glucose-monitoring device was made available on the U.K. National Health Service (NHS) drug tariff in 2017. This study aims to explore the U.K. real-world experience of FSL and the impact on glycemic control, hypoglycemia, diabetes-related distress, and hospital admissions. Clinicians from 102 NHS hospitals in the U.K. submitted FSL user data, collected during routine clinical care, to a secure web-based tool held within the NHS N3 network. The and Mann-Whitney tests were used to compare the baseline and follow-up HbA and other baseline demographic characteristics. Linear regression analysis was used to identify predictors of change in HbA following the use of FSL. Within-person variations of HbA were calculated using Formula: see text. Data were available for 10,370 FSL users (97% with type 1 diabetes), age 38.0 (±18.8) years, 51% female, diabetes duration 16.0 (±49.9) years, and BMI of 25.2 (±16.5) kg/m (mean ±SD). FSL users demonstrated a -5.2 mmol/mol change in HbA , reducing from 67.5 (±20.9) mmol/mol (8.3%) at baseline to 62.3 (±18.5) mmol/mol (7.8%) after 7.5 (interquartile range 3.4-7.8) months of follow-up ( = 3,182) ( < 0.0001). HbA reduction was greater in those with initial HbA ≥69.5 mmol/mol (>8.5%), reducing from 85.5 (±16.1) mmol/mol (10%) to 73.1 (±15.8) mmol/mol (8.8%) ( < 0.0001). The baseline Gold score (score for hypoglycemic unawareness) was 2.7 (±1.8) and reduced to 2.4 (±1.7) ( < 0.0001) at follow-up. A total of 53% of those with a Gold score of ≥4 at baseline had a score <4 at follow-up. FSL use was also associated with a reduction in diabetes distress ( < 0.0001). FSL use was associated with a significant reduction in paramedic callouts and hospital admissions due to hypoglycemia and hyperglycemia/diabetic ketoacidosis. We show that the use of FSL was associated with significantly improved glycemic control and hypoglycemia awareness and a reduction in hospital admissions.
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