E-resources
Peer reviewed
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Kremer, I; Robinson, A; Braffman, M; Drucker, M; Goldenfeld, M; Samra, Z; Myszne-Daye, N; Gaton, D; Savir, H
Cornea, 1994-July, Volume: 13, Issue: 4Journal Article
Ceftazidime is a beta-lactam antibiotic highly effective against Pseudomonas aeruginosa infection. Using a rabbit model of Pseudomonas keratitis, 10(3) bacteria (in 20 microliters) were injected unilaterally into the corneal stroma of albino rabbits. Twenty-six hours after inoculation, topical Ceftazidime (50 mg/ml) drops were administered for 48 h, following which the corneal tissue was cultured. Eighteen of 20 corneal cultures (90%) from rabbits treated with Ceftazidime drops were negative. In comparison, all untreated control group cultures showed florid bacterial growth. These results suggest that topical Ceftazidime may be a useful agent in the treatment of P. aeruginosa keratitis.
