Brain tumor as a second malignant neoplasm following neuroblastoma stage IV S

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Brain tumor as a second malignant neoplasm following neuroblastoma stage IV S

Ben-Arush, M W; Doron, Y; Braun, J; Mendelsson, E; Dar, H; Robinson, E

Medical and pediatric oncology, 1990, Volume: 18, Issue: 3

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A rare brain tumor (spongioblastoma polare) occurring 7 years after treatment of neuroblastoma stage IV S is reported. The literature concerning the occurrence of a second cancer in children exposed to mutagenic therapy for their initial tumor is reviewed, and genetic and environmental factors are discussed. Diminishing aggressiveness of the treatment in childhood cancer with good prognosis should be considered. Continuous follow-up of children cured of cancer is warranted.

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