We report the detection of X-ray polarization in the neutron star low mass X-ray binary Scorpius (Sco) X-1 with PolarLight. The result is energy dependent, with a non-detection in 3-4 keV but a 4\(\sigma\) detection in 4-8 keV; it is also flux dependent in the 4-8 keV band, with a non-detection when the source displays low fluxes but a 5\(\sigma\) detection during high fluxes, in which case we obtain a polarization fraction of \(0.043 \pm 0.008\) and a polarization angle of \(52.6^\circ \pm 5.4^\circ\). This confirms a previous marginal detection with OSO-8 in the 1970s, and marks Sco X-1 the second astrophysical source with a significant polarization measurement in the keV band. The measured polarization angle is in line with the jet orientation of the source on the sky plane (\(54^\circ\)), which is supposedly the symmetric axis of the system. Combining previous spectral analysis, our measurements suggest that an optically thin corona is located in the transition layer under the highest accretion rates, and disfavor the extended accretion disk corona model.