Adiposity has been linked with mortality among Whites/Asians, but evidence from Hispanics is limited. We included 15855 adults from the Hispanic Community Health Study/Study of Latinos (2008-11). BMI, waist circumference (WC), waist-to-hip ratio (WHR), and body fat percentage (BF%) were measured, and Cox regressions estimated their relations with mortality. Over 153828 person years (median 10 years), 651 deaths occurred. With adjustment of sociodemographic and lifestyle covariates (Figure; Model 1), no dose-response relation of BMI or BF% with mortality was found. Compared with normal weight (BMI<25 kg/m2), only severe obesity (BMI≥35 kg/m2) was associated with higher mortality (HR=1.58, 95% CI 1.08-2.31). Central obesity was associated with higher mortality with HRs (95% CIs) of 1.41 (1.01-1.97) comparing WC of >102/88 cm (for men/women) vs ≤94/80 cm and 1.70 (1.14-2.53) comparing WHR of ≥0.90/0.85 vs <0.90/0.85. With further adjustment of baseline comorbidities (Figure; Model 2), only WHR remained associated with mortality. BMI was highly correlated with BF% and WC (r>0.84) but not WHR (r=0.54). WHR remained associated with mortality after further adjusting for BMI. Sex suggestively modified the relation of WHR with mortality which was stronger among women. Among US Hispanic/Latino adults, only severe obesity was associated with higher mortality. WHR could predict mortality better and should be evaluated in bodyweight management. Disclosure Y.Zhang: None. R.Kaplan: None. Q.Qi: None. G.Chen: None. D.Sotres-alvarez: None. K.M.Perreira: None. L.Gallo: None. M.M.Llabre: None. J.Cai: None. X.Xue: None. C.R.Isasi: None. Funding National Institute of Diabetes and Digestive and Kidney Diseases (R01DK119268, R01DK120870, P30DK111022); National Heart, Lung, and Blood Institute (HHSN268201300001I/N01-HC-65233, HHSN268201300004I/N01-HC-65234, HHSN268201300002I/N01-HC-65235, HHSN268201300003I/N01-HC-65236, HHSN268201300005I/N01-HC-65237)