In the field of chemical and biological defence, technical and technological developments have followed those of threats and risks. As a result, the means of detection, identification, protection, decontamination and medical, preventive or curative treatments have been significantly improved. CBRN defence More efficient, faster and especially more reliable, the equipment has undeniably made it possible to improve the CBRN defences in particular in these specific areas in order to better cope with major events. Without being exhaustive, this paper proposes to present the most significant developments in the field of chemical and biological defence, including the use of Robotics Systems, knowing that technical and technological developments have also been significant in the nuclear and radiological fields which will not be discussed here. Robotics: The Mobile Robotics Systems begin to emerge in applications related to the security and the environmental surveillance: prevention of disasters, intervention during disasters, assistance to Fire-Fighting and/or Protection Services, with all possible kinds of mission ensuring the safety of the human beings.