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Peer reviewed
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Kazanova, G V; Tsorin, I B; Chichkanov, G G; Zakharov, S P; Shchegolev, A I; Iavorskiĭ, A N; Liubimov, B I
Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ, 1992 May-Jun, Volume: 55, Issue: 3Journal Article
Experiments on rats with myocardial infarction induced by occlusion of the left coronary artery were made to explore the influence of calcium antagonists injected intraperitoneally for a long time (daily, for 21 days) on hemodynamics, contractile function and morphology of the heart muscle. It has been shown that verapamil (0.5 mg/kg), diltiazem (2 mg/kg) and nimodipine (20 micrograms/kg) do not exert under those conditions any noticeable effect on pump and contractile heart functions. Administration of verapamil in a doze of 2 mg/kg enhanced heart failure. The drugs under study normalized the response of contractile heart function to volumetric load, which is related to a considerable measure to the acceleration of reparative processes in the myocardium.
