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Maslah, Nabih; Ravdan, Odonchimeg; Drevon, Louis; Verger, Emmanuelle; Belkhodja, Célia; Chomienne, Christine; Cassinat, Bruno; Kiladjian, Jean‐Jacques; Giraudier, Stéphane; Schlageter, Marie‐Hélène
British journal of haematology, February 2022, 2022-02-00, 20220201, Volume: 196, Issue: 3Journal Article
Summary We assessed the diagnostic performances of erythropoietin and JAK2 mutations in 1,090 patients with suspected polycythemia who were referred for red cell mass (RCM) measurement. In patients with a high haematocrit and/or haemoglobin level, a low erythropoietin level (<=3·3 mUI/ml) and JAK2 mutation showed comparable positive predictive value (PPV) for true polycythemia (RCM>=125%), 92·1% and 90% respectively. A very‐low erythropoietin level (<=1·99 mUI/ml) had a PPV of 100% for polycythemia vera (PV) diagnosis. We confirmed the correlations between RCM, erythropoietin and JAK2 variant allelic frequency in PV patients. This study prompts the need to revisit the role of EPO in PV diagnostic criteria.
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