Mechanisms of Acquired In Vivo and In Vitro Resistance to Voriconazole by Candida krusei following Exposure to Suboptimal Drug Concentration

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Mechanisms of Acquired In Vivo and In Vitro Resistance to Voriconazole by Candida krusei following Exposure to Suboptimal Drug Concentration

Ricardo, Elisabete; Grenouillet, Fréderic; Miranda, Isabel M; Silva, Raquel M; Eglin, Guilluame; Devillard, Nadège; Rodrigues, Acácio Gonçalves; Pina-Vaz, Cidália

Antimicrobial agents and chemotherapy, 03/2020, Volume: 64, Issue: 4

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Five isolates (susceptible and resistant) recovered from the urine of a kidney transplant patient treated with voriconazole (VRC) 200 mg twice daily for 20 days were studied. Eight unrelated clinical isolates of were exposed to VRC 0.001 μg/ml for 30 days. Development of VRC transient resistance occurred , and induction of permanent resistance occurred Mostly, and genes were overexpressed, and a homozygous T418C mutation in the gene was found.

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