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Steele, R.B.; Nugent, W.H.; Braswell, S.F.; Frisch, S.; Ferrell, J.; Ortega-Loayza, A.G.
British journal of dermatology (1951), January 2016, Volume: 174, Issue: 1Journal Article
Summary Pyoderma gangrenosum (PG) is a neutrophil‐predominant inflammatory disease that initially presents as a sterile pustule and may progress to ulcerations. Its root cause is unknown, but the presentation is commonly associated with systemic inflammatory conditions such as inflammatory bowel disease, arthritis and haematological abnormalities. On the other hand, pregnant women show a progressive neutrophilia during gestation, which culminates in a major inflammatory event to help drive labour. Although uncommonly, PG has been associated with pregnancy, which provides an additional link to systemic inflammation as an underlying cause of PG. We reviewed documented presentations of PG in gravid and post‐partum patients, and have speculated on the possible pathogenesis based on their clinical presentations. Also, we summarize the reported treatments and their outcomes in these patients. What's already known about this topic? Pyoderma gangrenosum (PG) is rarely associated with pregnancy. What does this study add? We reviewed 26 cases of pregnancy‐associated PG and speculated on the pathogenesis. Alterations in the immune system during pregnancy may predispose certain patients to PG. Understanding the pathogenesis of PG and its associated conditions is important for proper diagnosis and targeted therapy. Treatment can be challenging due to the possible detrimental side‐effects from medications, not only to the mother's health but also to the fetus.
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