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Miyata‐Morita, Kana; Morita, Shigeki; Matsutani, Noriyuki; Kondo, Fukuo; Soejima, Yurie; Sawabe, Motoji
Pathology international, December 2019, Volume: 69, Issue: 12Journal Article
Anaplastic lymphoma kinase‐rearranged (ALK+) lung cancers show characteristic histological features, such as solid signet ring cell patterns and mucinous cribriform patterns; however, these features are not always observed in ALK+ lung cancers. We noticed that club cell (Clara cell)‐like cells (CLCs) were frequently present in the papillary portion of ALK+ lung adenocarcinomas. In this study, we investigated the importance of CLCs in papillary patterns of ALK+ lung cancers. We compared the histological features of 18 ALK+ cases with 62 control cases (22 epidermal growth factor receptor‐positive (EGFR+) and 40 ALK‐ and EGFR‐negative (ALK−/EGFR−) cases). The present study analyzed presence of papillary pattern, proportion of papillary pattern area, presence of micropapillary pattern, frequency of CLCs and lengths of snout. The frequency of CLCs in ALK+ cases was significantly higher than that in EGFR+ cases and ALK−/EGFR− cases. Micropapillary pattern was more frequently observed in ALK+ cases than that in ALK−/EGFR− cases (P < 0.001). The present study indicated that the high frequency of CLCs in papillary patterns was significantly associated with ALK+ cases. When solid signet ring cell patterns and mucinous cribriform patterns are absent, the high frequency of CLCs in papillary adenocarcinoma could be a useful histological marker for ALK+ lung cancers.
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