First Description of an Escherichia coli Strain Producing NDM-1 Carbapenemase in Spain

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First Description of an Escherichia coli Strain Producing NDM-1 Carbapenemase in Spain

Solé, Mar; Pitart, Cristina; Roca, Ignasi; Fàbrega, Anna; Salvador, Pilar; Muñoz, Laura; Oliveira, Inés; Gascón, Joaquim; Marco, Francesc; Vila, Jordi

Antimicrobial Agents and Chemotherapy, 09/2011, Volume: 55, Issue: 9

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A carbapenem-resistant Escherichia coli strain (DVR22) was recovered from a stool specimen from a patient with traveler's diarrhea who had traveled to India. Molecular screening led to the first identification of NDM-1 in Spain. The blaNDM-1 gene was located in a conjugative plasmid of ca. 300 kb that also contained the blaCTX-M-15, blaTEM-1, ΔblaDHA-1, and armA genes. In addition, blaNDM-1 was preceded by an ISAba125 insertion element only found in Acinetobacter spp.

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