The Catalytic Mechanisms of Binuclear Metallohydrolases

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The Catalytic Mechanisms of Binuclear Metallohydrolases

Mitić, Nataša; Smith, Sarah J; Neves, Ademir; Guddat, Luke W; Gahan, Lawrence R; Schenk, Gerhard

Chemical reviews, 08/2006, Volume: 106, Issue: 8

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Binuclear metallohydrolases are a structurally diverse group of enzymes that use binuclear metal ion centers to catalyze the hydrolysis of amides and esters of carboxylic and phosphoric acids. A current understanding of metallohydrolase-catalyzed reactions is presented.

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