The ocean skin is composed of thin interfacial microlayers of temperature and mass of less than 1 mm where heat and chemical exchanges are controlled by molecular diffusion. It is characterized by a cooling of ∼−0.2 K and an increase in salinity of ∼0.1 g/kg (absolute salinity) relative to the water below. A surface observation‐based air‐sea CO2 flux estimate considering the variation of the CO2 concentration in these microlayers has been shown to lead to an increase in the global ocean sink of the anthropogenic CO2 by +0.4 PgC yr−1 (15% of the global sink). This study analyzes this effect in more details using a 15‐year (2000–2014) simulation from an Earth System Model (ESM) that incorporates a physical representation of the ocean surface layers (diurnal warm layer and rain lenses) and microlayers. Results show that considering the microlayers increases the simulated global ocean carbon sink by +0.26 to +0.37 PgC yr−1 depending on assumptions on the chemical equilibrium. This is indeed about 15% of the global sink (2.04 PgC yr−1) simulated by the ESM. However, enabling the ocean skin adjustment to feedback on ocean carbon concentrations reduces this increase to only +0.13 (±0.09) PgC y−1. Coupled models underestimate the ocean carbon sink by ∼5% if the ocean skin effect is not included. Plain Language Summary The ocean skin is a thin layer of less than a millimeter that is in contact with the atmosphere, where the heat and chemical exchanges are controlled by molecular diffusion. It typically corresponds to a temperature at the ocean interface that is cooler by −0.2 K than the water at a depth of a millimeter. It also corresponds to a salinity that is slightly higher at the interface. Taking into account these temperature and salinity changes in this thin layer can change calculations of the global ocean carbon sink substantially. We use a global Earth System Model including a representation of the ocean skin to study this impact. We found an increase of 15% in the simulated global ocean carbon sink. This is consistent with past studies. Enabling the flux to feedback on the ocean carbon concentration significantly reduces its impact. We conclude by discussing the uncertainties in the global ocean carbon sink associated with the formulation of the carbon flux and the representation of the ocean skin. Key Points Considering the ocean skin increases the global ocean CO2 sink by +0.26 to +0.37 PgC yr−1 (∼15% for 2000–2014) in an Earth System Model Enabling the ocean skin adjustment to feedback on ocean carbon concentrations dampens this increase to +0.13 PgC y−1 (∼5% for 2000–2014) This global adjustment depends on the CO2 flux formulation and ultimately on the model capacity to transfer CO2 into the ocean interior