Pchaeglobolactone A, Spiropchaeglobosin A, and Pchaeglobosals A and B: Four Rearranged Cytochalasans from Chaetomium globosum P2-2‑2

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Pchaeglobolactone A, Spiropchaeglobosin A, and Pchaeglobosals A and B: Four Rearranged Cytochalasans from Chaetomium globosum P2-2‑2

Peng, Xiao-Gang; Liu, Junjun; Gao, Ying; Cheng, Fang; Chang, Jin-Ling; Chen, Juan; Duan, Fang-Fang; Ruan, Han-Li

Organic letters, 12/2020, Volume: 22, Issue: 24

Journal Article

Four novel rearranged cytochalasans (1–4) were isolated from an endophytic fungus Chaetomium globosum P2-2-2. Pchaeglobolactone A (1) possessed an unprecedented 13-aza-21-oxa-tetracyclo-10.6.1.217,19.015,19henicosane core. Spiropchaeglobosin A (2) was the first example of cytochalasans featuring a novel spiro5.10hexadecane unit. Pchaeglobosals A (3) and B (4) featured a unique 5/5/13 fused tricyclic ring system. Compounds 1–4 were tested for their antiproliferative, apoptosis, cell cycle arrest, and TRAIL-resistance-overcoming activities on cancer cell lines.

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