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Li, Dan; Rui, Yi-xin; Guo, Shi-duo; Luan, Fei; Liu, Rong; Zeng, Nan
Life sciences (1973), 11/2021, Volume: 284Journal Article
Ferulic acid, a kind of phenolic substance widely existing in plants, is an important active component of many traditional Chinese medicines. So far, it has been proved that ferulic acid has a variety of biological activities, especially in oxidative stress, inflammation, vascular endothelial injury, fibrosis, apoptosis and platelet aggregation. Many studies have shown that ferulic acid can inhibit PI3K/AKT pathway, the production of ROS and the activity of aldose reductase. The anti-inflammatory effect of ferulic acid is mainly related to the levels of PPAR γ, CAM and NF-κ B and p38 MAPK signaling pathways. Ferulic acid not only protects vascular endothelium by ERK1/2 and NO/ET-1 signal, but also plays an anti-fibrosis role by TGF-β/Smad and MMPs/TIMPs system. Moreover, ferulic acid has ant-apoptotic and anti-platelet effects. In addition to the pharmacological effects of ferulic acid, its pharmacokinetics and derivatives were also discussed in this paper. This review provides the latest summary of the latest research on ferulic acid. Display omitted •This is a pioneer review of ferulic acid and its derivatives.•Ferulic acid and its derivatives present diverse biological functions.•Ferulic acid is promising molecule to treat vascular disorders.•Ferulic acid and its derivatives have strong antioxidant activity.
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