Time to blur the blast boundaries

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Time to blur the blast boundaries

DiNardo, Courtney D.; Garcia‐Manero, Guillermo; Kantarjian, Hagop M.

Cancer, April 15, 2022, Volume: 128, Issue: 8

Journal Article

A fixed 20% blast percentage to discriminate myelodysplastic neoplasms from acute myeloid leukemia is arbitrary and overly simplistic. Key factors for identifying the optimal therapy for a patient with a myeloid malignancy should rely most on the patient's characteristics (particularly age and fitness/frailty) and disease cytogenetic and mutational profile, with less reliance on the bone marrow blast percentage.

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DiNardo, Courtney D. | Garcia‐Manero, Guillermo | Kantarjian, Hagop M.

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