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Wang(b), Jie; Wang, Shudong; Xiao, Mengjie; Zhang, Jingjing; Wang(a), Jie; Guo, Yuanfang; Tang, Yufeng; Gu, Junlian
Pharmacological research, February 2021, 2021-Feb, 2021-02-00, 20210201, Volume: 164Journal Article
Display omitted Sestrin2 (Sesn2) is a powerful anti-oxidant that can prevent acute and chronic diseases. The role of Sesn2 has been thoroughly reviewed in liver, nervous system, and immune system diseases. However, there is a limited number of reviews that have summarized the effects of Sesn2 in heart and vascular diseases, and very less literature-based information is available on involvement of Sesn2 in renal and respiratory pathologies. This review summarizes the latest research on Sesn2 in multi-organ stress responses, with a particular focus on the protective role of Sesn2 in cardiovascular, respiratory, and renal diseases, emphasizing the potential therapeutic benefit of targeting Sesn2 in stress-related diseases.
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